How Some People Are Resistant To HIV?


Campbell Biology

Source: Urry, Lisa A.. Campbell Biology (p. 130). Pearson Education. Kindle Edition.

Proteins on a cell’s surface are important in the medical field. For example, a protein called CD4 on the surface of immune cells helps the human immunodeficiency virus (HIV) infect these cells, leading to acquired immune deficiency syndrome (AIDS). Despite multiple exposures to HIV, however, a small number of people do not develop AIDS and show no evidence of HIV-infected cells. Comparing their genes with the genes of infected individuals, researchers learned that resistant people have an unusual form of a gene that codes for an immune cell-surface protein called CCR5. Further work showed that although CD4 is the main HIV receptor, HIV must also bind to CCR5 as a “co-receptor” to infect most cells. An absence of CCR5 on the cells of resistant individuals, due to the gene alteration, prevents the virus from entering the cells. This information has been key to developing a treatment for HIV infection. Interfering with CD4 causes dangerous side effects because of its many important functions in cells. Discovery of the CCR5 co-receptor provided a safer target for development of drugs that mask this protein and block HIV entry. One such drug, maraviroc (brand name Selzentry), was approved for treatment of HIV in 2007 and is now being tested to determine whether this drug might also work to prevent HIV infection in uninfected, at-risk patients.


Urry, Lisa A.. Campbell Biology. Pearson Education. Kindle Edition.


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