Research Highlights: A Robust Human Norovirus Replication Model in Zebrafish Larvae

The high-resolution cryo-EM structures of three different forms of the human norovirus shells (Credit: James Jung) Source: https://www.cshl.edu/ Original Article: http://doi.org/10.1371/journal.ppat.1008009 Human noroviruses (HuNoVs) are the most common cause of foodborne illness, with a societal cost of $60 billion and 219,000 deaths/year. Norovirus is a very contagious virus that causes vomiting and diarrhea. HuNoVs are … Continue reading Research Highlights: A Robust Human Norovirus Replication Model in Zebrafish Larvae

Research Highlights: Dietary Zinc and its Association with Streptococcus pneumoniae Infection

Streptococcus pneumoniae. Image Source: http://hit-micrscopewb.hc.msu.edu/Microbiology/Lab/S1-Resp_Image_06.html Original Article: https://doi.org/10.1371/journal.ppat.1007957 Zinc is a nutrient that people need to stay healthy, and it is found in cells throughout the body. Zinc helps the immune system fight off invading bacteria and viruses. The body also needs zinc to make proteins and DNA, the genetic material in all cells. Human … Continue reading Research Highlights: Dietary Zinc and its Association with Streptococcus pneumoniae Infection

Research Highlights: The History of New Dimorphic Fungal Pathogen: Emergomyces

Potential model for exposure and pathogenesis of Emergomyces.1) Emergomyces species exist in soil in a mold phase, from where 2) conidia are released and aerosolized. 3) Upon inhalation by humans, the conidia undergo a temperature-dependent transformation in the lungs to yeast-like cells that replicate by budding and are capable of causing pulmonary disease in susceptible … Continue reading Research Highlights: The History of New Dimorphic Fungal Pathogen: Emergomyces

Research Highlights: CRISPR-based genetics and Tuberculosis Drug Discovery

Image Source: https://med.stanford.edu/ Original Article: https://doi.org/10.1371/journal.ppat.1007975 Tuberculosis (TB) is caused by a bacterium called Mycobacterium tuberculosis (Mtb). The bacteria usually attack the lungs, but TB bacteria can attack any part of the body such as the kidney, spine, and brain.  Professor Stewart Cole is an internationally acclaimed scientist, and has published more than 350 scientific papers … Continue reading Research Highlights: CRISPR-based genetics and Tuberculosis Drug Discovery

Research Highlights: Influenza Virus Infected Cells Survive Immune Response

Image Source: https://www.open.edu/ Influenza A virus (IAV) is a seasonal pathogen with the potential to cause devastating pandemics. Type A influenza infection can be serious and cause widespread outbreaks and disease. IAV infects multiple epithelial cell subsets in the respiratory tract, eliciting damage to the lungs. Epithelial cells line the outer surfaces of organs and … Continue reading Research Highlights: Influenza Virus Infected Cells Survive Immune Response

Research Highlights: Spatial and temporal regularization to estimate COVID-19 reproduction number R(t): Promoting piecewise smoothness via convex optimization

Image Source: https://theconversation.com/r0-how-scientists-quantify-the-intensity-of-an-outbreak-like-coronavirus-and-predict-the-pandemics-spread-130777 Basic reproductive number is the expected number of cases directly generated by one case in a population where all individuals are susceptible to infection. For example, if an infected person transmits the disease to three other people, then the reproductive number for that infectious disease is three. The higher the reproductive number, … Continue reading Research Highlights: Spatial and temporal regularization to estimate COVID-19 reproduction number R(t): Promoting piecewise smoothness via convex optimization

Research Highlights: The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion

Malaria is a mosquito-borne disease caused by a parasite. People with malaria often experience fever, chills, and flu-like illness. Left untreated, they may develop severe complications and die. Plasmodium falciparum is a unicellular protozoan parasite of humans, and the deadliest species of Plasmodium that causes malaria in humans. The parasite is transmitted through the bite … Continue reading Research Highlights: The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion

Research Highlights: Molecular Clock of Mycobacterium Tuberculosis

Image Source: https://med.stanford.edu/ Mycobacterium tuberculosis is an acid fast, nonmotile, obligate anaerobe. These bacilli range in size from 2-4 µm and have an incredibly slow generation time of 15 to 20 hours. The genus of Mycobacterium is defined by the mycolic acids and waxes, which makes the bacterium resistant to many bactericidal agents. For this … Continue reading Research Highlights: Molecular Clock of Mycobacterium Tuberculosis

Research Highlights: Young Women Diagnosed with Breast Cancer in Geneva, Switzerland

Image Source: https://www.mit.edu Breast cancer is a disease in which cells in the breast grow out of control. There are different kinds of breast cancer. The kind of breast cancer depends on which cells in the breast turn into cancer. Breast cancer is the most frequently diagnosed cancer among women worldwide. Despite the fact that … Continue reading Research Highlights: Young Women Diagnosed with Breast Cancer in Geneva, Switzerland

Research Abstract: A contribution to age determination of cheetahs (Acinonyx jubatus) based on radiographic analysis of the skull and postcranial morphology

Date Published: June 11, 2019 Publisher: Public Library of Science Author(s): Martin J. Schmidt, Gerhard Steenkamp, Klaus Failing, Peter Caldwell, Robert M. Kirberger, Andrew Cuff. http://doi.org/10.1371/journal.pone.0217999 The cheetah's closest relatives are the cougar and the jaguarundi. Together, these three species form the Puma lineage, one of the eight lineages of the extant felids; the Puma lineage diverged from … Continue reading Research Abstract: A contribution to age determination of cheetahs (Acinonyx jubatus) based on radiographic analysis of the skull and postcranial morphology