Original Article: https://doi.org/10.18632/aging.100578
- Lithocholic acid is a class of organic compounds known as monohydroxy bile acids, alcohols and derivatives, and has been found in human hepatic tissue, intestine and liver tissues, and has also been primarily detected in bile, feces, urine, and blood.
- This study revealed that lithocholic acid is a strong anti-aging natural compound that in yeast cultured under longevity-extending caloric restriction conditions, acts in synergy with caloric restriction to enable a significant further increase in chronological lifespan.
- This study investigate a mechanism underlying this robust longevity-extending effect of lithocholic acid under caloric restriction.
- Researchers found that exogenously added lithocholic acid enters yeast cells, is sorted to mitochondria, resides mainly in the inner mitochondrial membrane, and also associates with the outer mitochondrial membrane.
- Lithocholic acid elicits an age-related remodeling of glycerophospholipid synthesis and movement within both mitochondrial membranes.
- The age-related remodeling synthesis and movement are causing substantial changes in mitochondrial membrane lipidome and triggering major changes in mitochondrial size, number and morphology.
- Lipidome is comprised of all of the biomolecules defined as lipids.
- In synergy, these changes in the membrane lipidome and morphology of mitochondria alter the age-related chronology of mitochondrial respiration, membrane potential, ATP synthesis and reactive oxygen species homeostasis.
- The lithocholic acid-driven alterations in the age-related dynamics of these vital mitochondrial processes extend yeast longevity.
- In totally, the findings suggest a mechanism underlying the ability of lithocholic acid to delay chronological aging in yeast by accumulating in both mitochondrial membranes and altering their glycerophospholipid compositions.
- The study concluded that mitochondrial membrane lipidome plays an essential role in defining yeast longevity.