Research Highlights: Genes Related to the Development of Alcoholism


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  • Genetic factors account for a considerable portion of the risk for alcoholism.
  • It is challenging to identify those genes and the specific variations.
  • Case-control and family studies were used to identify genes related to the risk for alcohol.
  • Different strategies such as candidate gene analyses and genome-wide association studies have been used.
  • The strongest effects have been found for specific variants of genes that encode two enzymes involved in alcohol metabolism.
  • The two enzyme are alcohol dehydrogenase and aldehyde dehydrogenase.
  • Alcohol dehydrogenases are a class of zinc enzymes which catalyze the oxidation of primary and secondary alcohols to the corresponding aldehyde or ketone.
  • Aldehyde dehydrogenases are the workforce for several cellular processes, including detoxification of alcohol-derived acetaldehyde, and formation of essential molecules, such as retinoic acid.
  • Accumulating evidence indicates that variations in numerous other genes have smaller but measurable effects.

Source:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711246/

https://www.sciencedirect.com/topics/neuroscience/alcohol-dehydrogenase

https://www.sciencedirect.com/topics/medicine-and-dentistry/aldehyde-dehydrogenase


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