Research Highlights: Macrophages Perform Quality Check in Colon Fluid Absorption

Original Source: https://doi.org/10.1016/j.cell.2020.08.048

  • The primary function of the colon is to absorb fluids.
  • The colon contains a large number of microorganisms including fungi, which are elevated near the end of the segment.
  • The mucous membrane of the colon must regulate fluid influx to control absorption of metabolites from fungi.
  • Fungal metabolites can be toxic to epithelial cells and lead to barrier dysfunction.
  • The mechanism of the fluid influx regulation is still unclear.
  • The study describe a mechanism by which the immune system is associated with quality checking the fluid absorption to avoid intoxication of epithelial cells of the colon.
  • The mechanism relies on a number of distal colon macrophages attached to the epithelium.
  • If the macrophages are not present, epithelial cells keep absorbing fluids containing fungal products.
  • When epithelial cells absorb fungal products, they die and the epithelial barrier losses integrity.
  • The data reveal an essential role of macrophages in the maintenance of colon-microbiota interactions in homeostasis.

Source:

https://doi.org/10.1016/j.cell.2020.08.048


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Keywords: how fluids in colon are filtered, what cleans fluid in colon, colon fluid filtration, colon fluid absorption regulation, regulation of fluid in colon, role of macrophages in colon

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