Research Highlights: Monitoring the Placebo Effect with Plasma Proteins in Nausea

Original Article: https://doi.org/10.1371/journal.pone.0238533

  • Researchers tested whether placebo effects can be monitored and predicted by plasma proteins.
  • Participants were exposed to a nauseating stimulus on two separate days.
  • Participants were randomly assigned to placebo treatment or no treatment on the second day.
  • Significant placebo effects on nausea, motion sickness, and gastric activity in females could be verified.
  • Using a type of mass spectrometry, 74 differentially regulated proteins were identified that correlates with the placebo effect.
  • Gene ontology enrichment analyses identified acute-phase proteins and microinflammatory proteins to be involved.
  • Gene ontology provides a framework and set of concepts for describing the functions of gene products from all organisms.
  • Acute phase proteins are plasma proteins synthesized in the liver whose concentrations increase or decrease during inflammation.
  • The identified gene ontology signatures predicted day-adjusted scores of nausea indices in the placebo group.
  • Researchers also performed gene ontology enrichment analyses of specific plasma proteins predictable by the experimental factors or their interactions and identified ‘grooming behavior’ as an important hit.
  • Graphical analysis allowed to identify plasma proteins differentiating placebo responders from non-responders, comprising immunoglobulins and proteins involved in oxidation reduction processes and complement activation.
  • The study of plasma proteins is a promising tool to identify molecular correlation and prediction of the placebo effect in humans.

Source:

https://doi.org/10.1371/journal.pone.0238533

https://link.springer.com/protocol/10.1007/978-1-4939-3743-1_2

https://www.sciencedirect.com/book/9780323357753/pathologic-basis-of-veterinary-disease


Advertisements

Advertisements

Keywords: can placebo effect be monitored, can we measure the effect of placebo, placebo effect measurement, tracking placebo effect, monitoring placebo effect, detection of placebo effect

Leave a Reply

Your email address will not be published.