Original Article: https://doi.org/10.1016/j.cell.2020.11.029
- The COVID-19 virus is causing worldwide pandemic.
- COVID-19 cases continue to increase.
- Most COVID-19 infections are associated with mild symptoms.
- However, it is unclear whether mild COVID-19 infection can induce immune response which could contribute to immunity.
- Researchers evaluated people who recovered from mild COVID-19 infection to determine if they develop COVID-19 specific immunity.
- Researchers determined that individuals developed COVID-19-specific antibodies, neutralizing plasma, and memory cells that continued for more than 3 months.
- Data also revealed COVID-19-specific IgG memory B cells increased over time.
- Memory T cells have shown potent antiviral function such cytokine secretion.
- Memory T cells are antigen-specific T cells that remain long-term after an infection has been eliminated.
- Memory B cells expressed proteins capable of fighting virus.
- Memory B cells remember the same pathogen for faster antibody production in future infections.
- Mild COVID-19 infection induce memory immune cells that persist and show functions related to antiviral immunity.
Rodda, L. B., Netland, J., Shehata, L., Pruner, K. B., Morawski, P. A., Thouvenel, C. D., Takehara, K. K., Eggenberger, J., Hemann, E. A., Waterman, H. R., Fahning, M. L., Chen, Y., Hale, M., Rathe, J., Stokes, C., Wrenn, S., Fiala, B., Carter, L., Hamerman, J. A., King, N. P., … Pepper, M. (2020). Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19. Cell, S0092-8674(20)31565-8. Advance online publication. https://doi.org/10.1016/j.cell.2020.11.029