Research Highlights: Immunity Persist After Mild COVID-19 Infection

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Original Article: https://doi.org/10.1016/j.cell.2020.11.029

  • The COVID-19 virus is causing worldwide pandemic.
  • COVID-19 cases continue to increase.
  • Most COVID-19 infections are associated with mild symptoms.
  • However, it is unclear whether mild COVID-19 infection can induce immune response which could contribute to immunity.
  • Researchers evaluated people who recovered from mild COVID-19 infection to determine if they develop COVID-19 specific immunity.
  • Researchers determined that individuals developed COVID-19-specific antibodies, neutralizing plasma, and memory cells that continued for more than 3 months.
  • Data also revealed COVID-19-specific IgG memory B cells increased over time.
  • Memory T cells have shown potent antiviral function such cytokine secretion.
  • Memory T cells are antigen-specific T cells that remain long-term after an infection has been eliminated.
  • Memory B cells expressed proteins capable of fighting virus.
  • Memory B cells remember the same pathogen for faster antibody production in future infections.
  • Mild COVID-19 infection induce memory immune cells that persist and show functions related to antiviral immunity.

Source:

Rodda, L. B., Netland, J., Shehata, L., Pruner, K. B., Morawski, P. A., Thouvenel, C. D., Takehara, K. K., Eggenberger, J., Hemann, E. A., Waterman, H. R., Fahning, M. L., Chen, Y., Hale, M., Rathe, J., Stokes, C., Wrenn, S., Fiala, B., Carter, L., Hamerman, J. A., King, N. P., … Pepper, M. (2020). Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19. Cell, S0092-8674(20)31565-8. Advance online publication. https://doi.org/10.1016/j.cell.2020.11.029

https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/memory-t-cell

https://en.wikipedia.org/wiki/Memory_B_cell#/media/File:Original_antigenic_sin.svg


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