Research Highlights: Inhibition of Prostaglandin-Degrading Enzyme Improves Aged Muscle Mass, Strength, and Performance

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Original Article: https://doi.org/10.1126/science.abc8059

  • Sarcopenia is a condition characterized by age-related loss of skeletal muscle mass and function.
  • Currently, sarcopenia treatments are lacking.
  • Increase in enzyme that degrades prostaglandin is a hallmark of old tissues including skeletal muscle.
  • The reduction of prostaglandin signaling is the main contributor to the reduction of muscle mass in aged mice.
  • Researchers found that myofibers and interstitial cells within the old muscle produce the prostaglandin-degrading enzymes.
  • Inhibition of prostaglandin-degrading enzymes increases aged muscle mass, strength, and performance.
  • Inhibition of prostaglandin-degrading enzymes rejuvenated prostaglandin levels which increase mitochondrial function and damaged cell clean ups.
  • Inhibition of prostaglandin-degrading enzymes also decreases ubiquitin-proteasome pathways which is associate with protein degradation.
  • The study demonstrate how prostaglandin can counter muscle mass reduction.
  • The result suggests that prostaglandin-degrading enzymes is a potential therapeutic target to treat sarcopenia.

Source:

Palla, A. R., Ravichandran, M., Wang, Y. X., Alexandrova, L., Yang, A. V., Kraft, P., Holbrook, C. A., Schürch, C. M., Ho, A., & Blau, H. M. (2020). Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength. Science (New York, N.Y.), eabc8059. Advance online publication. https://doi.org/10.1126/science.abc8059

https://pubmed.ncbi.nlm.nih.gov/25568649/

https://www.frontiersin.org/articles/10.3389/fnmol.2016.00004/full


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