Research Highlights: Immune Memory to COVID-19 Virus Assessed for up to 8 Months after Infection

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Original Article: https://doi.org/10.1126/science.abf4063

  • Understanding SARS-CoV-2 immune memory is important for diagnostics and vaccine improvements.
  • The future course of the COVID-19 pandemic is likely dependent on our knowledge of the disease.
  • Researchers analyzed multiple compartments of circulating immune memory to SARS-CoV-2.
  • Number of samples analyzed: 254
  • Number of COVID-19 cases analyzed: 188
  • The study includes 43 samples taken from more than 6 months after infection.
  • IgG antibodies to the spike protein was relatively stable over 6 months.
  • Spike-specific memory B cells were higher in concentration at 6 months compared to 1st month during the start of symptoms.
  • SARS-CoV-2-specific CD4+ T cells and CD8+ T cells declined with a half-life of 3-5 months.
  • Researchers observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics.

Source:

Dan, J. M., Mateus, J., Kato, Y., Hastie, K. M., Yu, E. D., Faliti, C. E., Grifoni, A., Ramirez, S. I., Haupt, S., Frazier, A., Nakao, C., Rayaprolu, V., Rawlings, S. A., Peters, B., Krammer, F., Simon, V., Saphire, E. O., Smith, D. M., Weiskopf, D., Sette, A., … Crotty, S. (2021). Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection. Science (New York, N.Y.), eabf4063. Advance online publication. https://doi.org/10.1126/science.abf4063

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