Research Highlights: Cancer Cells Evade Death from Chemotherapy

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Cancer Cells Evade Death from Chemotherapy

Original Article: https://doi.org/10.1016/j.cell.2020.11.018

  • Cancer cells enter a state where it can evade death from chemotherapy and targeted agents.
  • During this death evasion state, therapy failure and tumor relapse may occur.
  • Researchers identify and characterize the cancer cell death evasion in response to chemotherapy.
  • Researchers utilized cellular barcoding and mathematical modeling in patient-derived colorectal cancer models.
  • Analysis revealed that therapy has no effect on tumors that entered death evasion state.
  • Additionally, recurrence is followed after ending treatment.
  • Data shows that all cancer cells have the ability to become immortal to chemotherapy.
  • Researchers determined that the death evasion state is transcriptionally and functionally similar to diapause.
  • Diapause occurs when the development of an embryo is suspended in response to unfavorable environmental conditions.
  • The study provides more understanding into how cancer cells use a developmentally conserved mechanism to drive the death evasion state.
  • The result demands a new therapeutic opportunities to target the death evasion mechanism.

Related Research: Research Article: A Novel Serum Metabolomics-Based Diagnostic Approach for Colorectal Cancer

Source:

Rehman, S. K., Haynes, J., Collignon, E., Brown, K. R., Wang, Y., Nixon, A., Bruce, J. P., Wintersinger, J. A., Singh Mer, A., Lo, E., Leung, C., Lima-Fernandes, E., Pedley, N. M., Soares, F., McGibbon, S., He, H. H., Pollet, A., Pugh, T. J., Haibe-Kains, B., Morris, Q., … O’Brien, C. A. (2021). Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy. Cell184(1), 226–242.e21. https://doi.org/10.1016/j.cell.2020.11.018

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Related External Link:

Patterns of metastasis in colon and rectal cancer