Research Highlights: Excessive Exercise Linked to Mitochondrial Functional Impairment and Reduction of Glucose Tolerance

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Excessive Exercise Linked to Mitochondrial Functional Impairment and Reduction of Glucose Tolerance

  • Exercise can have a positive effect on metabolic health.
  • Exercise can increase mitochondrial oxidative capacity and improve regulation of glucose.
  • Exercise is initially encouraged to treat a number of metabolic diseases.
  • However, the association between therapeutic benefits and excessive exercise has not been clear.
  • Researchers used training model with increasing exercise level during a 4 week intervention.
  • Glucose tolerance, mitochondrial function/dynamics, physical exercise capacity, and whole-body metabolism were monitored during the experiment.
  • The result shows that mitochondrial function was reduced after the highest exercise level.
  • The mitochondrial function reduction occurred simultaneously with the disruption in glucose tolerance and insulin production.
  • Researchers also analyzed blood glucose in world-class endurance athletes and found that the glucose control was impaired.

Source:

Flockhart, M., Nilsson, L. C., Tais, S., Ekblom, B., Apró, W., & Larsen, F. J. (2021). Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers. Cell metabolism, S1550-4131(21)00102-9. Advance online publication. https://doi.org/10.1016/j.cmet.2021.02.017

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