Butyrate Produced by Gut Microbiome Can Improve Antitumor Responses of T Cells
- Studies have shown that gut microbiota can regulate tumor responsiveness to chemotherapy or immunotherapy.
- However, the mechanism of this regulation is not clear.
- Researchers found that metabolites from gut microbiota can increase the effectiveness of oxaliplatin by regulating CD8+ T cell function in the tumor microenvironment.
- Oxaliplatin is a drug used to treat colon and rectal cancer.
- Butyrate is one of the metabolites produced by the gut microbiota.
- Butyrate treatment improved the antitumor responses of cytotoxic CD8+ T cell by promoting the IL-12 signaling pathway.
- IL-12 signaling pathway is associated with the activation of innate and adaptive immune responses.
- Cancer patients that responded to oxaliplatin showed higher level of serum butyrate.
- High level of serum butyrate can improve ID2 expression and CD8+ T cell function.
- The results suggest that butyrate produced by gut microbiota can improve antitumor responses of CD8+ T cells.
He, Y., Fu, L., Li, Y., Wang, W., Gong, M., Zhang, J., Dong, X., Huang, J., Wang, Q., Mackay, C. R., Fu, Y. X., Chen, Y., & Guo, X. (2021). Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity. Cell metabolism, S1550-4131(21)00109-1. Advance online publication. https://doi.org/10.1016/j.cmet.2021.03.002 https://www.drugs.com/mtm/oxaliplatin.html
Date Published: August 25, 2009 Publisher: Public Library of Science Author(s): Steven A. L. W. Vanhoutvin, Freddy J. Troost, Henrike M. Hamer, Patrick J. Lindsey, Ger H. Koek, Daisy M. A. E. Jonkers, Andrea Kodde, Koen Venema, Robert J. M. Brummer, Stefan Bereswill http://doi.org/10.1371/journal.pone.0006759 Abstract: Fermentation of dietary fiber in the colon results in the production … Continue reading
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Research Article: A Proteomic View at the Biochemistry of Syntrophic Butyrate Oxidation in Syntrophomonas wolfei
Date Published: February 26, 2013 Publisher: Public Library of Science Author(s): Alexander Schmidt, Nicolai Müller, Bernhard Schink, David Schleheck, Ivo G. Boneca. http://doi.org/10.1371/journal.pone.0056905 Abstract: In syntrophic conversion of butyrate to methane and CO2, butyrate is oxidized to acetate by secondary fermenting bacteria such as Syntrophomonas wolfei in close cooperation with methanogenic partner organisms, e.g., Methanospirillum hungatei. … Continue reading