Scientists Mixed Human Cells with Monkey Cells to Create Chimeric Embryos
- Human stem cells introduced to cells from other species may be a necessary alternative to assess its ability to differentiate inside a living organism.
- This process might establish a promising technique for various regenerative medicine applications which includes generating organs and tissues for transplantation.
- In mouse and pig embryonic studies, human pluripotent stem cells do not strongly contribute to chimera formation in species that are distant from humans.
- Chimera is an individual organism or molecule derived from 2 or more species.
- This research studied the chimeric formation of human stem cells when introduced into monkey embryos.
- The study comprised researchers from Gene Expression Laboratory in California, State Key Laboratory of Primate Biomedical Research in China, and Universidad Católica San Antonio de Murcia in Spain.
- Researchers discovered that the human stem cells were able to survive, proliferate, and generate implantation cell lineages inside the monkey embryos.
- Researchers also discovered that the human stem cells and monkey embryonic cells seem to communicate with each other that can lead to the unique development of chimeric embryos.
- The findings may help our understanding of human development and primate evolution and develop techniques to improve human chimerism in evolutionarily distant species.