Research Article: Isolation of a natural DNA virus of Drosophila melanogaster, and characterisation of host resistance and immune responses

Date Published: June 4, 2018 Publisher: Public Library of Science Author(s): William H. Palmer, Nathan C. Medd, Philippa M. Beard, Darren J. Obbard, Jean-Luc Imler. http://doi.org/10.1371/journal.ppat.1007050 Abstract Drosophila melanogaster has played a key role in our understanding of invertebrate immunity. However, both functional and evolutionary studies of host-virus interaction in Drosophila have been limited by … Continue reading Research Article: Isolation of a natural DNA virus of Drosophila melanogaster, and characterisation of host resistance and immune responses

Research Article: Origins of DNA replication

Date Published: September 12, 2019 Publisher: Public Library of Science Author(s): Babatunde Ekundayo, Franziska Bleichert Abstract: In all kingdoms of life, DNA is used to encode hereditary information. Propagation of the genetic material between generations requires timely and accurate duplication of DNA by semiconservative replication prior to cell division to ensure each daughter cell receives … Continue reading Research Article: Origins of DNA replication

Research Article: A DNA Virus of Drosophila

Date Published: October 28, 2011 Publisher: Public Library of Science Author(s): Robert L. Unckless, Robert DeSalle. http://doi.org/10.1371/journal.pone.0026564 Abstract: Little is known about the viruses infecting most species. Even in groups as well-studied as Drosophila, only a handful of viruses have been well-characterized. A viral metagenomic approach was used to explore viral diversity in 83 wild-caught Drosophila … Continue reading Research Article: A DNA Virus of Drosophila

Research Article: A DNA structural alphabet provides new insight into DNA flexibility

Date Published: January 01, 2018 Publisher: International Union of Crystallography Author(s): Bohdan Schneider, Paulína Božíková, Iva Nečasová, Petr Čech, Daniel Svozil, Jiří Černý. http://doi.org/10.1107/S2059798318000050 Abstract Large deformations of the DNA double helix induced by interactions with proteins and small molecules are necessary to support the biological function of DNA. Here, the software tools available at … Continue reading Research Article: A DNA structural alphabet provides new insight into DNA flexibility

Research Article: Unexpected DNA Loss Mediated by the DNA Binding Activity of Ribonuclease A

Date Published: December 11, 2014 Publisher: Public Library of Science Author(s): Federico Donà, Jonathan Houseley, Sander Granneman. http://doi.org/10.1371/journal.pone.0115008 Abstract Ribonuclease A (RNase A) is widely used in molecular biology research both for analytical assays and for nucleic acid preparation. The catalytic mechanism of RNase A is well understood and absolutely precludes activity on DNA; however … Continue reading Research Article: Unexpected DNA Loss Mediated by the DNA Binding Activity of Ribonuclease A

Research Article: A Mechanism for the Inhibition of DNA-PK-Mediated DNA Sensing by a Virus

Date Published: October 3, 2013 Publisher: Public Library of Science Author(s): Nicholas E. Peters, Brian J. Ferguson, Michela Mazzon, Aodhnait S. Fahy, Ewelina Krysztofinska, Raquel Arribas-Bosacoma, Laurence H. Pearl, Hongwei Ren, Geoffrey L. Smith, Michele Barry. http://doi.org/10.1371/journal.ppat.1003649 Abstract The innate immune system is critical in the response to infection by pathogens and it is activated … Continue reading Research Article: A Mechanism for the Inhibition of DNA-PK-Mediated DNA Sensing by a Virus

Research Article: Platinum nanoparticles induce damage to DNA and inhibit DNA replication

Date Published: July 12, 2017 Publisher: Public Library of Science Author(s): Lukas Nejdl, Jiri Kudr, Amitava Moulick, Dagmar Hegerova, Branislav Ruttkay-Nedecky, Jaromir Gumulec, Kristyna Cihalova, Kristyna Smerkova, Simona Dostalova, Sona Krizkova, Marie Novotna, Pavel Kopel, Vojtech Adam, Hélder A. Santos. http://doi.org/10.1371/journal.pone.0180798 Abstract Sparsely tested group of platinum nanoparticles (PtNPs) may have a comparable effect as … Continue reading Research Article: Platinum nanoparticles induce damage to DNA and inhibit DNA replication