Research Article: HIV Treatment-as-Prevention Research at a Crossroads

Date Published: June 3, 2014 Publisher: Public Library of Science Author(s): Till Bärnighausen, Nir Eyal, Daniel Wikler Abstract: In light of changing WHO guidelines for HIV treatment, Till Bärnighausen and colleagues consider how large-scale HIV treatment-as-prevention trials can be adapted so that they can remain viable.Please see later in the article for the Editors’ Summary … Continue reading Research Article: HIV Treatment-as-Prevention Research at a Crossroads

Research Article: HIV control: Is getting there the same as staying there?

Date Published: November 1, 2018 Publisher: Public Library of Science Author(s): Philip Goulder, Steven G. Deeks, Carolyn B. Coyne. http://doi.org/10.1371/journal.ppat.1007222 Abstract In this brief review and perspective, we address the question of whether the immune responses that bring about immune control of acute HIV infection are the same as, or distinct from, those that maintain … Continue reading Research Article: HIV control: Is getting there the same as staying there?

Research Article: HIV Restriction by APOBEC3 in Humanized Mice

Date Published: March 28, 2013 Publisher: Public Library of Science Author(s): John F. Krisko, Francisco Martinez-Torres, John L. Foster, J. Victor Garcia, Michael Emerman. http://doi.org/10.1371/journal.ppat.1003242 Abstract Innate immune restriction factors represent important specialized barriers to zoonotic transmission of viruses. Significant consideration has been given to their possible use for therapeutic benefit. The apolipoprotein B mRNA … Continue reading Research Article: HIV Restriction by APOBEC3 in Humanized Mice

Research Article: HIV epidemics in Shenzhen and Chongqing, China

Date Published: February 15, 2018 Publisher: Public Library of Science Author(s): Shu Yang, Alice P. Y. Chiu, Qianying Lin, Ziqian Zeng, Yafei Li, Yao Zhang, Zhengrong Yang, Lin Yang, Daihai He, Gerardo Chowell. http://doi.org/10.1371/journal.pone.0192849 Abstract Men who have sex with men (MSM) and heterosexuals are the populations with the fastest growing HIV infection rates in … Continue reading Research Article: HIV epidemics in Shenzhen and Chongqing, China

Research Article: HIV Induces TRAIL Sensitivity in Hepatocytes

Date Published: February 27, 2009 Publisher: Public Library of Science Author(s): Challagundla K. Babu, Kanitta Suwansrinon, Gary D. Bren, Andrew D. Badley, Stacey A. Rizza, Derya Unutmaz. http://doi.org/10.1371/journal.pone.0004623 Abstract: HIV infected patients have an increased susceptibility to liver disease due to Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), alcoholic, and non-alcoholic steatohepatitis. Clinically, this results … Continue reading Research Article: HIV Induces TRAIL Sensitivity in Hepatocytes

Research Article: HIV Self-testing and the Missing Linkage

Date Published: October 4, 2011 Publisher: Public Library of Science Author(s): Rochelle P. Walensky, Ingrid V. Bassett Abstract: Rochelle Walensky and Ingrid Bassett discuss new research in PLoS Medicine that assessed the feasibility of home-based oral HIV self-testing in Malawi, and suggest that linkage to care must be demonstrated before the success of oral self-testing … Continue reading Research Article: HIV Self-testing and the Missing Linkage

Research Article: HIV status disclosure during acute HIV infection in Malawi

Date Published: July 26, 2018 Publisher: Public Library of Science Author(s): Sayaka Hino, Catherine Grodensky, Sarah E. Rutstein, Carol Golin, M. Kumi Smith, Lawrenson Christmas, William Miller, Sam Phiri, Cecilia Massa, Gift Kamanga, Audrey Pettifor, Jesse L. Clark. http://doi.org/10.1371/journal.pone.0201265 Abstract Diagnosis of acute HIV infection (AHI) presents an opportunity to prevent HIV transmission during a … Continue reading Research Article: HIV status disclosure during acute HIV infection in Malawi

Research Article: HIV p24 as Scaffold for Presenting Conformational HIV Env Antigens

Date Published: August 17, 2012 Publisher: Public Library of Science Author(s): Maria Tagliamonte, Daniela Marasco, Alessia Ruggiero, Angelo De Stradis, Maria Lina Tornesello, Maxim Totrov, Franco Maria Buonaguro, Luigi Buonaguro, Roger Le Grand. http://doi.org/10.1371/journal.pone.0043318 Abstract Heterologous protein scaffolds engrafted with structurally defined HIV Env epitopes recognized by broadly neutralizing monoclonal antibodies (MAbs) represent a promising strategy … Continue reading Research Article: HIV p24 as Scaffold for Presenting Conformational HIV Env Antigens