Research Article: Virus Control Goes Epigenetic

Date Published: September 11, 2014 Publisher: Public Library of Science Author(s): Jing-hsiung James Ou, Glenn F. Rall. http://doi.org/10.1371/journal.ppat.1004370 Abstract Partial Text Cells have developed a number of mechanisms to detect and suppress microbial infections. The use of pattern recognition receptors (PRRs) is one such mechanism. PRRs may be expressed on the cell surface, in the … Continue reading Research Article: Virus Control Goes Epigenetic

Research Article: Virus and Host Determinants of West Nile Virus Pathogenesis

Date Published: June 26, 2009 Publisher: Public Library of Science Author(s): Michael S. Diamond, Hiten D. Madhani. http://doi.org/10.1371/journal.ppat.1000452 Abstract Partial Text West Nile virus (WNV) is a small, enveloped, mosquito-transmitted, positive-stranded RNA virus of the Flaviviridae family. This virus is related to other arthropod-borne viruses that cause human disease globally, including dengue, yellow fever, and … Continue reading Research Article: Virus and Host Determinants of West Nile Virus Pathogenesis

Research Article: Virus–Host Interactions and the ARTD/PARP Family of Enzymes

Date Published: March 24, 2016 Publisher: Public Library of Science Author(s): Chad V. Kuny, Christopher S. Sullivan, Katherine R. Spindler. http://doi.org/10.1371/journal.ppat.1005453 Abstract Partial Text The Poly ADP-Ribose Polymerases (PARPs), also called Diphtheria toxin-like ADP-Ribosyltransferases (ARTDs), catalyze the transfer of ADP-Ribose from nicotinamide adenine dinucleotide (NAD+) to targeted proteins. The activity of these enzymes is generally … Continue reading Research Article: Virus–Host Interactions and the ARTD/PARP Family of Enzymes

Research Article: Virus-Encoded microRNAs: An Overview and a Look to the Future

Date Published: December 20, 2012 Publisher: Public Library of Science Author(s): Rodney P. Kincaid, Christopher S. Sullivan, Tom C. Hobman. http://doi.org/10.1371/journal.ppat.1003018 Abstract MicroRNAs (miRNAs) are small RNAs that play important roles in the regulation of gene expression. First described as posttranscriptional gene regulators in eukaryotic hosts, virus-encoded miRNAs were later uncovered. It is now apparent … Continue reading Research Article: Virus-Encoded microRNAs: An Overview and a Look to the Future

Research Article: Virus Infection Suppresses Nicotiana benthamiana Adaptive Phenotypic Plasticity

Date Published: February 17, 2011 Publisher: Public Library of Science Author(s): Stéphanie Bedhomme, Santiago F. Elena, Vladimir Uversky. http://doi.org/10.1371/journal.pone.0017275 Abstract: Competition and parasitism are two important selective forces that shape life-histories, migration rates and population dynamics. Recently, it has been shown in various pathosystems that parasites can modify intraspecific competition, thus generating an indirect cost of … Continue reading Research Article: Virus Infection Suppresses Nicotiana benthamiana Adaptive Phenotypic Plasticity

Research Article: Virus-Inspired Design Principles of Nanoparticle-Based Bioagents

Date Published: October 19, 2010 Publisher: Public Library of Science Author(s): Hongyan Yuan, Changjin Huang, Sulin Zhang, Alfred Lewin. http://doi.org/10.1371/journal.pone.0013495 Abstract: The highly effectiveness and robustness of receptor-mediated viral invasion of living cells shed lights on the biomimetic design of nanoparticle(NP)-based therapeutics. Through thermodynamic analysis, we elucidate that the mechanisms governing both the endocytic time of … Continue reading Research Article: Virus-Inspired Design Principles of Nanoparticle-Based Bioagents

Research Article: Virus Adaptation by Manipulation of Host’s Gene Expression

Date Published: June 11, 2008 Publisher: Public Library of Science Author(s): Patricia Agudelo-Romero, Pablo Carbonell, Miguel A. Perez-Amador, Santiago F. Elena, Maria G. Masucci. http://doi.org/10.1371/journal.pone.0002397 Abstract: Viruses adapt to their hosts by evading defense mechanisms and taking over cellular metabolism for their own benefit. Alterations in cell metabolism as well as side-effects of antiviral responses contribute … Continue reading Research Article: Virus Adaptation by Manipulation of Host’s Gene Expression

Research Article: Virus Satellites Drive Viral Evolution and Ecology

Date Published: October 23, 2015 Publisher: Public Library of Science Author(s): Belén Frígols, Nuria Quiles-Puchalt, Ignacio Mir-Sanchis, Jorge Donderis, Santiago F. Elena, Angus Buckling, Richard P. Novick, Alberto Marina, José R. Penadés, Harmit S. Malik Abstract: Virus satellites are widespread subcellular entities, present both in eukaryotic and in prokaryotic cells. Their modus vivendi involves parasitism … Continue reading Research Article: Virus Satellites Drive Viral Evolution and Ecology

Research Article: Virus Neutralisation: New Insights from Kinetic Neutralisation Curves

Date Published: February 28, 2013 Publisher: Public Library of Science Author(s): Carsten Magnus, Claus O. Wilke Abstract: Antibodies binding to the surface of virions can lead to virus neutralisation. Different theories have been proposed to determine the number of antibodies that must bind to a virion for neutralisation. Early models are based on chemical binding … Continue reading Research Article: Virus Neutralisation: New Insights from Kinetic Neutralisation Curves

Research Article: Virus Capsid Dissolution Studied by Microsecond Molecular Dynamics Simulations

Date Published: May 10, 2012 Publisher: Public Library of Science Author(s): Daniel S. D. Larsson, Lars Liljas, David van der Spoel, Michael Nilges Abstract: Dissolution of many plant viruses is thought to start with swelling of the capsid caused by calcium removal following infection, but no high-resolution structures of swollen capsids exist. Here we have … Continue reading Research Article: Virus Capsid Dissolution Studied by Microsecond Molecular Dynamics Simulations