Research Article: Brain Derived Neurotrophic Factor Contributes to the Cardiogenic Potential of Adult Resident Progenitor Cells in Failing Murine Heart

Date Published: March 23, 2015 Publisher: Public Library of Science Author(s): Rasmita Samal, Sabine Ameling, Vishnu Dhople, Praveen Kumar Sappa, Kristin Wenzel, Uwe Völker, Stephan B. Felix, Elke Hammer, Stephanie Könemann, Yaoliang Tang. http://doi.org/10.1371/journal.pone.0120360 Abstract Resident cardiac progenitor cells show homing properties when injected into the injured but not to the healthy myocardium. The molecular … Continue reading Research Article: Brain Derived Neurotrophic Factor Contributes to the Cardiogenic Potential of Adult Resident Progenitor Cells in Failing Murine Heart

Research Article: Angiopoietin-2 in Adults with Congenital Heart Disease and Heart Failure

Date Published: June 24, 2013 Publisher: Public Library of Science Author(s): Alexander Lukasz, Gernot Beutel, Philipp Kümpers, Agnieszka Denecke, Mechthild Westhoff-Bleck, Bernhard Schieffer, Johann Bauersachs, Jan T. Kielstein, Oktay Tutarel, Rajesh Gopalrao Katare. http://doi.org/10.1371/journal.pone.0066861 Abstract Chronic heart failure is an important cause for morbidity and mortality in adults with congenital heart disease (ACHD). While NT-proBNP is … Continue reading Research Article: Angiopoietin-2 in Adults with Congenital Heart Disease and Heart Failure

Research Article: A System for Heart Sounds Classification

Date Published: November 13, 2014 Publisher: Public Library of Science Author(s): Grzegorz Redlarski, Dawid Gradolewski, Aleksander Palkowski, Alena Talkachova. http://doi.org/10.1371/journal.pone.0112673 Abstract The future of quick and efficient disease diagnosis lays in the development of reliable non-invasive methods. As for the cardiac diseases – one of the major causes of death around the globe – a … Continue reading Research Article: A System for Heart Sounds Classification

Research Article: The effect of Tmem135 overexpression on the mouse heart

Date Published: August 13, 2018 Publisher: Public Library of Science Author(s): Sarah Aileen Lewis, Tetsuya Takimoto, Shima Mehrvar, Hitoshi Higuchi, Anna-Lisa Doebley, Giangela Stokes, Nader Sheibani, Sakae Ikeda, Mahsa Ranji, Akihiro Ikeda, Guo-Chang Fan. http://doi.org/10.1371/journal.pone.0201986 Abstract Tissues with high-energy demand including the heart are rich in the energy-producing organelles, mitochondria, and sensitive to mitochondrial dysfunction. … Continue reading Research Article: The effect of Tmem135 overexpression on the mouse heart

Research Article: ACE phenotyping in human heart

Date Published: August 3, 2017 Publisher: Public Library of Science Author(s): Victoria E. Tikhomirova, Olga A. Kost, Olga V. Kryukova, Elena Z. Golukhova, Naida I. Bulaeva, Aigerim Z. Zholbaeva, Leo A. Bokeria, Joe G. N. Garcia, Sergei M. Danilov, Michael Bader. http://doi.org/10.1371/journal.pone.0181976 Abstract Angiotensin-converting enzyme (ACE), which metabolizes many peptides and plays a key role … Continue reading Research Article: ACE phenotyping in human heart

Research Article: ACE phenotyping in human heart

Date Published: August 3, 2017 Publisher: Public Library of Science Author(s): Victoria E. Tikhomirova, Olga A. Kost, Olga V. Kryukova, Elena Z. Golukhova, Naida I. Bulaeva, Aigerim Z. Zholbaeva, Leo A. Bokeria, Joe G. N. Garcia, Sergei M. Danilov, Michael Bader. http://doi.org/10.1371/journal.pone.0181976 Abstract Angiotensin-converting enzyme (ACE), which metabolizes many peptides and plays a key role … Continue reading Research Article: ACE phenotyping in human heart

Research Article: Heterogeneity of T-Tubules in Pig Hearts

Date Published: June 9, 2016 Publisher: Public Library of Science Author(s): Hanne C. Gadeberg, Richard C. Bond, Cherrie H. T. Kong, Guillaume P. Chanoit, Raimondo Ascione, Mark B. Cannell, Andrew F. James, Vincenzo Lionetti. http://doi.org/10.1371/journal.pone.0156862 Abstract T-tubules are invaginations of the sarcolemma that play a key role in excitation-contraction coupling in mammalian cardiac myocytes. Although … Continue reading Research Article: Heterogeneity of T-Tubules in Pig Hearts

Research Article: The Emperor’s New Clothes: PDE5 and the Heart

Date Published: March 6, 2015 Publisher: Public Library of Science Author(s): Chantal V. Degen, Kalkidan Bishu, Rosita Zakeri, Ozgur Ogut, Margaret M. Redfield, Frank V. Brozovich, Rakesh Kukreja. http://doi.org/10.1371/journal.pone.0118664 Abstract Phosphodiesterase-5 (PDE5) is highly expressed in the pulmonary vasculature, but its expression in the myocardium is controversial. Cyclic guanosine monophosphate (cGMP) activates protein kinase G … Continue reading Research Article: The Emperor’s New Clothes: PDE5 and the Heart