Research Article: Estimation of Immune Cell Densities in Immune Cell Conglomerates: An Approach for High-Throughput Quantification

Date Published: November 16, 2009 Publisher: Public Library of Science Author(s): Niels Halama, Inka Zoernig, Anna Spille, Kathi Westphal, Peter Schirmacher, Dirk Jaeger, Niels Grabe, Syed A. Aziz. http://doi.org/10.1371/journal.pone.0007847 Abstract: Determining the correct number of positive immune cells in immunohistological sections of colorectal cancer and other tumor entities is emerging as an important clinical predictor and … Continue reading Research Article: Estimation of Immune Cell Densities in Immune Cell Conglomerates: An Approach for High-Throughput Quantification

Research Highlights: Immune Cell Response to COVID-19 Evolves in Few Months

Immune Cell Response to COVID-19 Evolve in Few Months Date: January 20, 2021 The COVID-19 virus has infected 78 million individuals. The COVID-19 virus is responsible for more than 1.7 million deaths. Infection is associated with development of varying levels of antibodies. The antibodies produced may come with neutralizing activity that can protect against infection … Continue reading Research Highlights: Immune Cell Response to COVID-19 Evolves in Few Months

Research Article: Ex Vivo Cytosolic Delivery of Functional Macromolecules to Immune Cells

Date Published: April 13, 2015 Publisher: Public Library of Science Author(s): Armon Sharei, Radiana Trifonova, Siddharth Jhunjhunwala, George C. Hartoularos, Alexandra T. Eyerman, Abigail Lytton-Jean, Mathieu Angin, Siddhartha Sharma, Roberta Poceviciute, Shirley Mao, Megan Heimann, Sophia Liu, Tanya Talkar, Omar F. Khan, Marylyn Addo, Ulrich H. von Andrian, Daniel G. Anderson, Robert Langer, Judy Lieberman, … Continue reading Research Article: Ex Vivo Cytosolic Delivery of Functional Macromolecules to Immune Cells

Research Highlights: Influenza Virus Infected Cells Survive Immune Response

Influenza A virus (IAV) is a seasonal pathogen with the potential to cause devastating pandemics. Type A influenza infection can be serious and cause widespread outbreaks and disease. IAV infects multiple epithelial cell subsets in the respiratory tract, eliciting damage to the lungs. Epithelial cells line the outer surfaces of organs and blood vessels throughout … Continue reading Research Highlights: Influenza Virus Infected Cells Survive Immune Response

Research Article: HIV-1 adaptation to NK cell-mediated immune pressure

Date Published: June 5, 2017 Publisher: Public Library of Science Author(s): Marjet Elemans, Lies Boelen, Michael Rasmussen, Søren Buus, Becca Asquith, Guido Silvestri. http://doi.org/10.1371/journal.ppat.1006361 Abstract The observation, by Alter et al., of the enrichment of NK cell “escape” variants in individuals carrying certain Killer-cell Immunoglobulin-like Receptor (KIR) genes is compelling evidence that natural killer (NK) … Continue reading Research Article: HIV-1 adaptation to NK cell-mediated immune pressure

Research Article: The human immune response to Toxoplasma: Autophagy versus cell death

Date Published: March 9, 2017 Publisher: Public Library of Science Author(s): Shruthi Krishnamurthy, Eleni K. Konstantinou, Lucy H. Young, Daniel A. Gold, Jeroen P. J. Saeij, Laura J Knoll. http://doi.org/10.1371/journal.ppat.1006176 Abstract Partial Text Toxoplasma gondii is an obligate intracellular parasite that can infect a broad range of warm-blooded animals. In humans, it can cause serious … Continue reading Research Article: The human immune response to Toxoplasma: Autophagy versus cell death

Research Article: MicroRNA Editing Facilitates Immune Elimination of HCMV Infected Cells

Date Published: February 27, 2014 Publisher: Public Library of Science Author(s): Daphna Nachmani, Albert Zimmermann, Esther Oiknine Djian, Yiska Weisblum, Yoav Livneh, Vu Thuy Khanh Le, Eithan Galun, Vaclav Horejsi, Ofer Isakov, Noam Shomron, Dana G. Wolf, Hartmut Hengel, Ofer Mandelboim, Shou-Jiang Gao. http://doi.org/10.1371/journal.ppat.1003963 Abstract The human cytomegalovirus (HCMV) is extremely prevalent in the human … Continue reading Research Article: MicroRNA Editing Facilitates Immune Elimination of HCMV Infected Cells

Research Article: Influence of Mast Cells on Dengue Protective Immunity and Immune Pathology

Date Published: December 19, 2013 Publisher: Public Library of Science Author(s): Ashley L. St. John, Vincent Racaniello. http://doi.org/10.1371/journal.ppat.1003783 Abstract Partial Text Mast cells (MCs) are sentinels for pathogens. They are situated in the skin and mucosae where pathogen encounter is common and surround blood vessels. MCs pre-store vasoactive mediators and cytokines in granules, such as … Continue reading Research Article: Influence of Mast Cells on Dengue Protective Immunity and Immune Pathology

Research Article: RAMP1 in Kupffer cells is a critical regulator in immune-mediated hepatitis

Date Published: November 21, 2018 Publisher: Public Library of Science Author(s): Tomoyoshi Inoue, Yoshiya Ito, Nobuyuki Nishizawa, Koji Eshima, Ken Kojo, Fumisato Otaka, Tomohiro Betto, Sakiko Yamane, Kazutake Tsujikawa, Wasaburo Koizumi, Masataka Majima, Wenyu Lin. http://doi.org/10.1371/journal.pone.0200432 Abstract The significance of the relationship between the nervous and immune systems with respect to disease course is increasingly … Continue reading Research Article: RAMP1 in Kupffer cells is a critical regulator in immune-mediated hepatitis

Research Article: Validation of Immune Cell Modules in Multicellular Transcriptomic Data

Date Published: January 3, 2017 Publisher: Public Library of Science Author(s): Gabriele Pollara, Matthew J. Murray, James M. Heather, Rachel Byng-Maddick, Naomi Guppy, Matthew Ellis, Carolin T. Turner, Benjamin M. Chain, Mahdad Noursadeghi, Ken Mills. http://doi.org/10.1371/journal.pone.0169271 Abstract Numerous gene signatures, or modules have been described to evaluate the immune cell composition in transcriptomes of multicellular … Continue reading Research Article: Validation of Immune Cell Modules in Multicellular Transcriptomic Data