Research Article: Estimation of Immune Cell Densities in Immune Cell Conglomerates: An Approach for High-Throughput Quantification

Date Published: November 16, 2009 Publisher: Public Library of Science Author(s): Niels Halama, Inka Zoernig, Anna Spille, Kathi Westphal, Peter Schirmacher, Dirk Jaeger, Niels Grabe, Syed A. Aziz. http://doi.org/10.1371/journal.pone.0007847 Abstract: Determining the correct number of positive immune cells in immunohistological sections of colorectal cancer and other tumor entities is emerging as an important clinical predictor and … Continue reading Research Article: Estimation of Immune Cell Densities in Immune Cell Conglomerates: An Approach for High-Throughput Quantification

Research Highlights: Immune Cell Response to COVID-19 Evolves in Few Months

Immune Cell Response to COVID-19 Evolve in Few Months Date: January 20, 2021 The COVID-19 virus has infected 78 million individuals. The COVID-19 virus is responsible for more than 1.7 million deaths. Infection is associated with development of varying levels of antibodies. The antibodies produced may come with neutralizing activity that can protect against infection … Continue reading Research Highlights: Immune Cell Response to COVID-19 Evolves in Few Months

Research Article: Immune-Related Concepts in Biology and Treatment of Germ-Cell Tumors

Date Published: March 13, 2018 Publisher: Hindawi Author(s): Michal Chovanec, Ugo De Giorgi, Michal Mego. http://doi.org/10.1155/2018/3718165 Abstract Germ-cell tumors (GCTs) are highly curable with chemotherapy. Salvage chemotherapy or surgery can cure a proportion of patients, but the ones failing these treatments will die of their disease in the young age. Immune checkpoint pathways are emerging … Continue reading Research Article: Immune-Related Concepts in Biology and Treatment of Germ-Cell Tumors

Research Article: Cellular senescence impact on immune cell fate and function

Date Published: February 22, 2016 Publisher: John Wiley and Sons Inc. Author(s): Rita Vicente, Anne‐Laure Mausset‐Bonnefont, Christian Jorgensen, Pascale Louis‐Plence, Jean‐Marc Brondello. http://doi.org/10.1111/acel.12455 Abstract Cellular senescence occurs not only in cultured fibroblasts, but also in undifferentiated and specialized cells from various tissues of all ages, in vitro and in vivo. Here, we review recent findings on the … Continue reading Research Article: Cellular senescence impact on immune cell fate and function

Research Article: Ex Vivo Cytosolic Delivery of Functional Macromolecules to Immune Cells

Date Published: April 13, 2015 Publisher: Public Library of Science Author(s): Armon Sharei, Radiana Trifonova, Siddharth Jhunjhunwala, George C. Hartoularos, Alexandra T. Eyerman, Abigail Lytton-Jean, Mathieu Angin, Siddhartha Sharma, Roberta Poceviciute, Shirley Mao, Megan Heimann, Sophia Liu, Tanya Talkar, Omar F. Khan, Marylyn Addo, Ulrich H. von Andrian, Daniel G. Anderson, Robert Langer, Judy Lieberman, … Continue reading Research Article: Ex Vivo Cytosolic Delivery of Functional Macromolecules to Immune Cells

Research Article: Polyelectrolyte‐Enrobed Cancer Cells in View of Personalized Immune‐Therapy

Date Published: May 02, 2017 Publisher: John Wiley and Sons Inc. Author(s): Lien Lybaert, Keun Ah Ryu, Riet De Rycke, Alfred C. Chon, Olivier De Wever, Karim Y. Vermaelen, Aaron Esser‐Kahn, Bruno G. De Geest. http://doi.org/10.1002/advs.201700050 Abstract Targeting the immune system with a personalized vaccine containing cues derived from the patient’s malignancy might be a … Continue reading Research Article: Polyelectrolyte‐Enrobed Cancer Cells in View of Personalized Immune‐Therapy

Research Article: The role of STIM and ORAI proteins in phagocytic immune cells

Date Published: April 1, 2016 Publisher: American Physiological Society Author(s): Nicolas Demaurex, Paula Nunes. http://doi.org/10.1152/ajpcell.00360.2015 Abstract Phagocytic cells, such as neutrophils, macrophages, and dendritic cells, migrate to sites of infection or damage and are integral to innate immunity through two main mechanisms. The first is to directly neutralize foreign agents and damaged or infected cells … Continue reading Research Article: The role of STIM and ORAI proteins in phagocytic immune cells

Research Highlights: Influenza Virus Infected Cells Survive Immune Response

Influenza A virus (IAV) is a seasonal pathogen with the potential to cause devastating pandemics. Type A influenza infection can be serious and cause widespread outbreaks and disease. IAV infects multiple epithelial cell subsets in the respiratory tract, eliciting damage to the lungs. Epithelial cells line the outer surfaces of organs and blood vessels throughout … Continue reading Research Highlights: Influenza Virus Infected Cells Survive Immune Response

Research Article: HIV-1 adaptation to NK cell-mediated immune pressure

Date Published: June 5, 2017 Publisher: Public Library of Science Author(s): Marjet Elemans, Lies Boelen, Michael Rasmussen, Søren Buus, Becca Asquith, Guido Silvestri. http://doi.org/10.1371/journal.ppat.1006361 Abstract The observation, by Alter et al., of the enrichment of NK cell “escape” variants in individuals carrying certain Killer-cell Immunoglobulin-like Receptor (KIR) genes is compelling evidence that natural killer (NK) … Continue reading Research Article: HIV-1 adaptation to NK cell-mediated immune pressure