acetyl CoA | definition

  • an activated carrier molecule consists of acetyl group linked to coenzyme A by thioester bond
  • delivers acetyl group to the Kreb cycle for energy production
  • participates in the synthesis of fatty acids and sterols


Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science.

Related Research

Research Article: Profiling of Cytosolic and Peroxisomal Acetyl-CoA Metabolism in Saccharomyces cerevisiae

Date Published: August 2, 2012 Publisher: Public Library of Science Author(s): Yun Chen, Verena Siewers, Jens Nielsen, Paul Cobine. Abstract: As a key intracellular metabolite, acetyl-coenzyme A (acetyl-CoA) plays a major role in various metabolic pathways that link anabolism and catabolism. In the yeast Saccharomyces cerevisiae, acetyl-CoA involving metabolism is compartmentalized, and may vary with … Continue reading

Research Article: Changes in Acetyl CoA Levels during the Early Embryonic Development of Xenopus laevis

Date Published: May 15, 2014 Publisher: Public Library of Science Author(s): Yugo Tsuchiya, Uyen Pham, Wanzhou Hu, Shin-ichi Ohnuma, Ivan Gout, Gert Jan C. Veenstra. Abstract: Coenzyme A (CoA) is a ubiquitous and fundamental intracellular cofactor. CoA acts as a carrier of metabolically important carboxylic acids in the form of CoA thioesters and is … Continue reading

Research Article: A Multienzyme Complex Channels Substrates and Electrons through Acetyl-CoA and Methane Biosynthesis Pathways in Methanosarcina

Date Published: September 18, 2014 Publisher: Public Library of Science Author(s): Dillon J. Lieber, Jennifer Catlett, Nandu Madayiputhiya, Renu Nandakumar, Madeline M. Lopez, William W. Metcalf, Nicole R. Buan, Vasu D. Appanna. Abstract: Multienzyme complexes catalyze important metabolic reactions in many organisms, but little is known about the complexes involved in biological methane production … Continue reading

Research Article: Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae

Date Published: February 23, 2017 Publisher: Public Library of Science Author(s): Meaghen Rollins, Sylvain Huard, Alan Morettin, Jennifer Takuski, Trang Thuy Pham, Morgan D. Fullerton, Jocelyn Côté, Kristin Baetz, Amy Caudy Abstract: Eukaryotic cells form stress granules under a variety of stresses, however the signaling pathways regulating their formation remain largely unknown. We have determined … Continue reading