acromegaly | definition

condition caused by overproduction of growth hormone in adults


Clark, M., Douglas, M., Choi, J. Biology 2e. Houston, Texas: OpenStax. Access for free at:

Research Article: Tumorigenesis of Papillary Thyroid Cancer Is Not BRAF-Dependent in Patients with Acromegaly

Date Published: October 17, 2014 Publisher: Public Library of Science Author(s): Hee Kyung Kim, Ji Shin Lee, Min Ho Park, Jin Seong Cho, Jee Hee Yoon, Soo Jeong Kim, Ho-Cheol Kang, Rafael Rosell. Abstract: Several studies have reported a high frequency of papillary thyroid cancer (PTC) in patients with acromegaly. The aim of this … Continue reading

Research Article: Neurocognitive Function in Acromegaly after Surgical Resection of GH-Secreting Adenoma versus Naïve Acromegaly

Date Published: April 4, 2013 Publisher: Public Library of Science Author(s): Juan Francisco Martín-Rodríguez, Ainara Madrazo-Atutxa, Eva Venegas-Moreno, Pedro Benito-López, María Ángeles Gálvez, David A. Cano, Francisco J. Tinahones, Elena Torres-Vela, Alfonso Soto-Moreno, Alfonso Leal-Cerro, Andrew Wolfe. Abstract: Patients with active untreated acromegaly show mild to moderate neurocognitive disorders that are associated to chronic exposure … Continue reading

Research Article: Gene Expression Signature in Adipose Tissue of Acromegaly Patients

Date Published: June 18, 2015 Publisher: Public Library of Science Author(s): Irit Hochberg, Quynh T. Tran, Ariel L. Barkan, Alan R. Saltiel, William F. Chandler, Dave Bridges, Martin Young. Abstract: To study the effect of chronic excess growth hormone on adipose tissue, we performed RNA sequencing in adipose tissue biopsies from patients with acromegaly … Continue reading

Research Article: The Role of Diabetes in Acromegaly Associated Neoplasia

Date Published: May 21, 2015 Publisher: Public Library of Science Author(s): Sonia Cheng, Karen Gomez, Omar Serri, Constance Chik, Shereen Ezzat, Raul M. Luque. Abstract: The risk and mortality due to cancer in patients with acromegaly have been previously investigated. Although GH/IGF-1 excess provides a probable pathophysiological explanation, the degree of IGF-1 excess and … Continue reading

Research Article: Meta-Analysis on the Effects of Octreotide on Tumor Mass in Acromegaly

Date Published: May 4, 2012 Publisher: Public Library of Science Author(s): Andrea Giustina, Gherardo Mazziotti, Valter Torri, Maurizio Spinello, Irene Floriani, Shlomo Melmed, Raul M. Luque. Abstract: The long-acting somatostatin analogue octreotide is used either as an adjuvant or primary therapy to lower growth hormone (GH) levels in patients with acromegaly and may also induce … Continue reading

Research Article: Place of Preoperative Treatment of Acromegaly with Somatostatin Analog on Surgical Outcome: A Systematic Review and Meta-Analysis

Date Published: April 25, 2013 Publisher: Public Library of Science Author(s): Francisco Pita-Gutierrez, Sonia Pertega-Diaz, Salvador Pita-Fernandez, Lara Pena, Gloria Lugo, Susana Sangiao-Alvarellos, Fernando Cordido, Raul M. Luque. Abstract Transsphenoidal neurosurgery is the accepted first-line treatment of acromegaly in the majority of patients. Previous studies addressing preoperative somatostatin analog (SSA) treatment and subsequent surgical cure … Continue reading

Research Article: Accelerated Telomere Shortening in Acromegaly; IGF-I Induces Telomere Shortening and Cellular Senescence

Date Published: October 8, 2015 Publisher: Public Library of Science Author(s): Ryusaku Matsumoto, Hidenori Fukuoka, Genzo Iguchi, Yukiko Odake, Kenichi Yoshida, Hironori Bando, Kentaro Suda, Hitoshi Nishizawa, Michiko Takahashi, Shozo Yamada, Wataru Ogawa, Yutaka Takahashi, Gabriele Saretzki. Abstract: Patients with acromegaly exhibit reduced life expectancy and increased prevalence of age-related diseases, such as diabetes, … Continue reading

Research Article: Increased Short-Term Beat-To-Beat Variability of QT Interval in Patients with Acromegaly

Date Published: April 27, 2015 Publisher: Public Library of Science Author(s): Andrea Orosz, Éva Csajbók, Csilla Czékus, Henriette Gavallér, Sándor Magony, Zsuzsanna Valkusz, Tamás T. Várkonyi, Attila Nemes, István Baczkó, Tamás Forster, Tibor Wittmann, Julius Gy. Papp, András Varró, Csaba Lengyel, Mathias Baumert. Abstract: Cardiovascular diseases, including ventricular arrhythmias are responsible for increased mortality … Continue reading