activation-induced deaminase (AID) | definition

  • an enzyme that catalyzes the processes of somatic hypermutation and antibody class switching in activated B lymphocytes

Source:

Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science. http://www.garlandscience.com/

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Related Research

Research Article: Activation-induced deaminase (AID) localizes to the nucleus in brief pulses

Date Published: February 27, 2019 Publisher: Public Library of Science Author(s): Quy Le, Nancy Maizels, Gregory S. Barsh Abstract: Activation-induced deaminase (AID) converts C to U and 5-methyl-C to T. These mutagenic activities are critical to immunoglobulin (Ig) gene diversification and epigenetic reprogramming, but they must be tightly controlled to prevent compromising cell fitness. AID … Continue reading

Research Article: Investigating epigenetic effects of activation-induced deaminase in chronic lymphocytic leukemia

Date Published: December 20, 2018 Publisher: Public Library of Science Author(s): Maria Schubert, Hubert Hackl, Franz Josef Gassner, Richard Greil, Roland Geisberger, Sebastian D. Fugmann. http://doi.org/10.1371/journal.pone.0208753 Abstract: Activation induced deaminase (AID) has two distinct and well defined roles, both relying on its deoxycytidine (dC) deaminating function: one as a DNA mutator and another in DNA … Continue reading

Research Article: Haploinsufficiency of Activation-Induced Deaminase for Antibody Diversification and Chromosome Translocations both In Vitro and In Vivo

Date Published: December 12, 2008 Publisher: Public Library of Science Author(s): Isora V. Sernández, Virginia G. de Yébenes, Yair Dorsett, Almudena R. Ramiro, Marta Feldmesser. http://doi.org/10.1371/journal.pone.0003927 Abstract: The humoral immune response critically relies on the secondary diversification of antibodies. This diversification takes places through somatic remodelling of the antibody genes by two molecular mechanisms, Class Switch … Continue reading

Research Article: Correction: Activation-induced deaminase (AID) localizes to the nucleus in brief pulses

Date Published: July 26, 2019 Publisher: Public Library of Science Author(s): unknown Abstract: None Partial Text: This article was republished on March 26, 2019 to correct an error in the ORCID iD of the corresponding author introduced during the typesetting process. The publisher apologizes for the errors. Please download this article again to view the … Continue reading

Research Article: Splice Variants of Activation Induced Deaminase (AID) Do Not Affect the Efficiency of Class Switch Recombination in Murine CH12F3 Cells

Date Published: March 24, 2015 Publisher: Public Library of Science Author(s): Cesare Sala, Giorgio Mattiuz, Silvia Pietrobono, Andrea Chicca, Silvestro G. Conticello, Sebastian D. Fugmann. http://doi.org/10.1371/journal.pone.0121719 Abstract: Activation Induced Deaminase (AID) triggers the antigen-driven antibody diversification processes through its ability to edit DNA. AID dependent DNA damage is also the cause of genetic alterations often … Continue reading

Research Article: Two Forms of Activation-Induced Cytidine Deaminase Differing in Their Ability to Bind Agarose

Date Published: January 27, 2010 Publisher: Public Library of Science Author(s): Mirjam Metzner, Wolfgang Schuh, Edith Roth, Hans-Martin Jäck, Matthias Wabl, Reuben S. Harris. http://doi.org/10.1371/journal.pone.0008883 Abstract: Activation-induced cytidine deaminase (AID) is a B-cell-specific DNA mutator that plays a key role in the formation of the secondary antibody repertoire in germinal center B cells. In the search … Continue reading