adaptor protein | definition

  • protein that links two or more different proteins in an intracellular signaling pathway or protein complex
adaptor protein
By Jawahar Swaminathan and MSD staff at the European Bioinformatics Institute –, displayed on, Public Domain,


Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science.

Related Research

Research Article: The Fifth Adaptor Protein Complex

Date Published: October 11, 2011 Publisher: Public Library of Science Author(s): Jennifer Hirst, Lael D. Barlow, Gabriel Casey Francisco, Daniela A. Sahlender, Matthew N. J. Seaman, Joel B. Dacks, Margaret S. Robinson, Sandra L. Schmid Abstract: Adaptor protein (AP) complexes sort cargo into vesicles for transport from one membrane compartment of the cell to another. … Continue reading

Research Article: A New Role for Clathrin Adaptor Proteins 1 and 3 in Lipoplex Trafficking

Date Published: March 11, 2014 Publisher: Public Library of Science Author(s): Justine E. Alford, Jade Gumbs, Emma C. Anderson, Matthew Seaman. Abstract: Intracellular protein trafficking through secretory and endocytic pathways depends on the function of adaptor proteins that bind motifs on cargo proteins. The adaptor proteins then recruit coat proteins such as clathrin, enabling … Continue reading

Research Article: Endocytic Adaptor Protein Tollip Inhibits Canonical Wnt Signaling

Date Published: June 25, 2015 Publisher: Public Library of Science Author(s): Anna Toruń, Ewelina Szymańska, Irinka Castanon, Lidia Wolińska-Nizioł, Anna Bartosik, Kamil Jastrzębski, Magdalena Miętkowska, Marcos González-Gaitán, Marta Miaczynska, Melanie Königshoff. Abstract: Many adaptor proteins involved in endocytic cargo transport exhibit additional functions in other cellular processes which may be either related to or … Continue reading

Research Article: Structural Basis for the Interaction of the Adaptor Protein Grb14 with Activated Ras

Date Published: August 13, 2013 Publisher: Public Library of Science Author(s): Rohini Qamra, Stevan R. Hubbard, Wenqing Xu. Abstract: Grb14, a member of the Grb7-10-14 family of cytoplasmic adaptor proteins, is a tissue-specific negative regulator of insulin signaling. Grb7-10-14 contain several signaling modules, including a Ras-associating (RA) domain, a pleckstrin-homology (PH) domain, a family-specific … Continue reading

Research Article: The Transmembrane Adaptor Protein SIT Inhibits TCR-Mediated Signaling

Date Published: September 21, 2011 Publisher: Public Library of Science Author(s): Börge Arndt, Tina Krieger, Thomas Kalinski, Anja Thielitz, Dirk Reinhold, Albert Roessner, Burkhart Schraven, Luca Simeoni, Jose Alberola-Ila. Abstract: Transmembrane adaptor proteins (TRAPs) organize signaling complexes at the plasma membrane, and thus function as critical linkers and integrators of signaling cascades downstream of antigen … Continue reading

Research Article: Adaptor Protein 1A Facilitates Dengue Virus Replication

Date Published: June 19, 2015 Publisher: Public Library of Science Author(s): Umpa Yasamut, Nopprarat Tongmuang, Pa-thai Yenchitsomanus, Mutita Junking, Sansanee Noisakran, Chunya Puttikhunt, Justin Jang Hann Chu, Thawornchai Limjindaporn, Xia Jin. Abstract: Rearrangement of membrane structure induced by dengue virus (DENV) is essential for replication, and requires host cellular machinery. Adaptor protein complex (AP)-1 … Continue reading

Research Article: Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death

Date Published: October 16, 2015 Publisher: Public Library of Science Author(s): José Manuel Molina-Guijarro, Carolina García, Álvaro Macías, Luis Francisco García-Fernández, Cristina Moreno, Fernando Reyes, Juan Fernando Martínez-Leal, Rogelio Fernández, Valentín Martínez, Carmen Valenzuela, M. Pilar Lillo, Carlos M. Galmarini, Hiroyasu Nakano. Abstract: Plasma membrane integrity is essential for cell life. Any major break … Continue reading