adenosine 5′-diphosphate (ADP) | definition

  • the product when the terminal phosphate of ATP is hydrolyzed
  • a nucleotide when phosphorylated becomes the energy-source molecule ATP


Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science.


Related Research

Research Article: Synthesis and Evaluation of a Novel Adenosine-Ribose Probe for Global-Scale Profiling of Nucleoside and Nucleotide-Binding Proteins

Date Published: February 11, 2015 Publisher: Public Library of Science Author(s): Shikha Mahajan, Roman Manetsch, David J. Merkler, Stanley M. Stevens Jr.. Abstract: Proteomics is a powerful approach used for investigating the complex molecular mechanisms of disease pathogenesis and progression. An important challenge in modern protein profiling approaches involves targeting of specific protein activities … Continue reading

Research Article: Antiplatelet Activity, P2Y1 and P2Y12 Inhibition, and Metabolism in Plasma of Stereoisomers of Diadenosine 5′,5′″-P1,P4-dithio-P2,P3-chloromethylenetetraphosphate

Date Published: April 10, 2014 Publisher: Public Library of Science Author(s): Hung Chang, Ivan B. Yanachkov, Edward J. Dix, Milka Yanachkova, YouFu Li, Marc R. Barnard, George E. Wright, Alan D. Michelson, Andrew L. Frelinger, Dermot Cox. Abstract: Diadenosine tetraphosphate (Ap4A), a constituent of platelet dense granules, and its P1,P4-dithio and/or P2,P3-chloromethylene analogs, inhibit … Continue reading

Research Article: Phosphatase-Coupled Universal Kinase Assay and Kinetics for First-Order-Rate Coupling Reaction

Date Published: August 11, 2011 Publisher: Public Library of Science Author(s): Zhengliang L. Wu, Vladimir N. Uversky. Abstract: Kinases use adenosine-5′-triphosphate (ATP) as the donor substrate and generate adenosine-5′-diphosphate (ADP) as a product. An ADP-based phosphatase-coupled kinase assay is described here. In this assay, CD39L2, a nucleotidase, is added into a kinase reaction to hydrolyze … Continue reading

Research Article: Structures of the Human Poly (ADP-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by ADP-HPD Derivatives

Date Published: December 10, 2012 Publisher: Public Library of Science Author(s): Julie A. Tucker, Neil Bennett, Claire Brassington, Stephen T. Durant, Giles Hassall, Geoff Holdgate, Mark McAlister, J. Willem M. Nissink, Caroline Truman, Martin Watson, Roland Seifert. Abstract: Poly(ADP-ribose) glycohydrolase (PARG) is the only enzyme known to catalyse hydrolysis of the O-glycosidic linkages of ADP-ribose … Continue reading

Research Article: Identification of a Tsetse Fly Salivary Protein with Dual Inhibitory Action on Human Platelet Aggregation

Date Published: March 23, 2010 Publisher: Public Library of Science Author(s): Guy Caljon, Karin De Ridder, Patrick De Baetselier, Marc Coosemans, Jan Van Den Abbeele, Anne Charlotte Gruner. Abstract: Tsetse flies (Glossina sp.), the African trypanosome vectors, rely on anti-hemostatic compounds for efficient blood feeding. Despite their medical importance, very few salivary proteins have been … Continue reading