adenylate cyclase | definition

an enzyme that catalyzes the conversion of ATP to cyclic AMP


Clark, M., Douglas, M., Choi, J. Biology 2e. Houston, Texas: OpenStax. Access for free at:

Research Article: Calcium-Dependent Increases in Protein Kinase-A Activity in Mouse Retinal Ganglion Cells Are Mediated by Multiple Adenylate Cyclases

Date Published: November 17, 2009 Publisher: Public Library of Science Author(s): Timothy A. Dunn, Daniel R. Storm, Marla B. Feller, Michael Hendricks. Abstract: Neurons undergo long term, activity dependent changes that are mediated by activation of second messenger cascades. In particular, calcium-dependent activation of the cyclic-AMP/Protein kinase A signaling cascade has been implicated in several … Continue reading

Research Article: Adenylate Cyclase Toxin Promotes Internalisation of Integrins and Raft Components and Decreases Macrophage Adhesion Capacity

Date Published: February 23, 2011 Publisher: Public Library of Science Author(s): César Martín, Kepa B. Uribe, Geraxane Gómez-Bilbao, Helena Ostolaza, Jérôme Nigou. Abstract: Bordetella pertussis, the bacterium that causes whooping cough, secretes an adenylate cyclase toxin (ACT) that must be post-translationally palmitoylated in the bacterium cytosol to be active. The toxin targets phagocytes expressing the … Continue reading

Research Article: Calpain-Mediated Processing of Adenylate Cyclase Toxin Generates a Cytosolic Soluble Catalytically Active N-Terminal Domain

Date Published: June 26, 2013 Publisher: Public Library of Science Author(s): Kepa B. Uribe, Aitor Etxebarria, César Martín, Helena Ostolaza, Mikael Skurnik. Abstract: Bordetella pertussis, the whooping cough pathogen, secretes several virulence factors among which adenylate cyclase toxin (ACT) is essential for establishment of the disease in the respiratory tract. ACT weakens host defenses … Continue reading

Research Article: Adenylate Cyclase Type III Is Not a Ubiquitous Marker for All Primary Cilia during Development

Date Published: January 25, 2017 Publisher: Public Library of Science Author(s): Maria Cristina Antal, Karelle Bénardais, Brigitte Samama, Cyril Auger, Valérie Schini-Kerth, Said Ghandour, Nelly Boehm, Shree Ram Singh. Abstract: Adenylate cyclase type III (AC3) is localized in plasma membrane of neuronal primary cilium and can be used as a marker of this cilium. … Continue reading

Research Article: Calcium Influx Rescues Adenylate Cyclase-Hemolysin from Rapid Cell Membrane Removal and Enables Phagocyte Permeabilization by Toxin Pores

Date Published: April 5, 2012 Publisher: Public Library of Science Author(s): Radovan Fiser, Jiri Masin, Ladislav Bumba, Eva Pospisilova, Catherine Fayolle, Marek Basler, Lenka Sadilkova, Irena Adkins, Jana Kamanova, Jan Cerny, Ivo Konopasek, Radim Osicka, Claude Leclerc, Peter Sebo, Steven R. Blanke. Abstract: Bordetella adenylate cyclase toxin-hemolysin (CyaA) penetrates the cytoplasmic membrane of phagocytes … Continue reading

Research Article: Bordetella Adenylate Cyclase Toxin Mobilizes Its β2 Integrin Receptor into Lipid Rafts to Accomplish Translocation across Target Cell Membrane in Two Steps

Date Published: May 13, 2010 Publisher: Public Library of Science Author(s): Ladislav Bumba, Jiri Masin, Radovan Fiser, Peter Sebo, Kenneth A. Bradley. Abstract: Bordetella adenylate cyclase toxin (CyaA) binds the αMβ2 integrin (CD11b/CD18, Mac-1, or CR3) of myeloid phagocytes and delivers into their cytosol an adenylate cyclase (AC) enzyme that converts ATP into the … Continue reading

Research Article: The Adenylate Cyclase Toxins of Bacillus anthracis and Bordetella pertussis Promote Th2 Cell Development by Shaping T Cell Antigen Receptor Signaling

Date Published: March 6, 2009 Publisher: Public Library of Science Author(s): Silvia Rossi Paccani, Marisa Benagiano, Nagaja Capitani, Irene Zornetta, Daniel Ladant, Cesare Montecucco, Mario M. D’Elios, Cosima T. Baldari, William Bishai. Abstract: The adjuvanticity of bacterial adenylate cyclase toxins has been ascribed to their capacity, largely mediated by cAMP, to modulate APC activation, … Continue reading

Research Article: Revealing how an adenylate cyclase toxin uses bait and switch tactics in its activation

Date Published: February 27, 2018 Publisher: Public Library of Science Author(s): Natosha L. Finley Abstract: Dissecting how bacterial pathogens escape immune destruction and cause respiratory infections in humans is a work in progress. One tactic employed by microbes is to use bacterial adenylate cyclase toxins (ACTs) to disarm immune cells and disrupt cellular signaling in … Continue reading

Research Article: Ca2+ Influx and Tyrosine Kinases Trigger Bordetella Adenylate Cyclase Toxin (ACT) Endocytosis. Cell Physiology and Expression of the CD11b/CD18 Integrin Major Determinants of the Entry Route

Date Published: September 13, 2013 Publisher: Public Library of Science Author(s): Kepa B. Uribe, César Martín, Aitor Etxebarria, David González-Bullón, Geraxane Gómez-Bilbao, Helena Ostolaza, Ludger Johannes. Abstract: Humans infected with Bordetella pertussis, the whooping cough bacterium, show evidences of impaired host defenses. This pathogenic bacterium produces a unique adenylate cyclase toxin (ACT) which enters … Continue reading

Research Article: Pituitary Adenylate Cyclase Activating Peptide Deficient Mice Exhibit Impaired Thymic and Extrathymic Regulatory T Cell Proliferation during EAE

Date Published: April 16, 2013 Publisher: Public Library of Science Author(s): Yossan-Var Tan, Catalina Abad, Yuqi Wang, Robert Lopez, James A. Waschek, Alexandre Salgado Basso. Abstract: We have shown that mice deficient in pituitary adenylate cyclase-activating polypeptide (PACAP, gene name ADCYAP1) manifest enhanced sensitivity to experimental autoimmune encephalomyelitis (EAE), supporting the anti-inflammatory actions described for … Continue reading