adherens junction | definition

  • a type of cell junction in which the cytoplasmic face of the plasma membrane is attached to actin filaments
  • include adhesion belts linking adjacent epithelial cells and focal contacts on the lower surface of cultured fibroblasts


Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science.


Related Research

Research Article: A Cell Motility Screen Reveals Role for MARCKS-Related Protein in Adherens Junction Formation and Tumorigenesis

Date Published: November 18, 2009 Publisher: Public Library of Science Author(s): Alexander E. Finlayson, Kevin W. Freeman, Juha Klefstrom. Abstract: Invasion through the extracellular matrix (ECM) is important for wound healing, immunological responses and metastasis. We established an invasion-based cell motility screen using Boyden chambers overlaid with Matrigel to select for pro-invasive genes. By this … Continue reading

Research Article: Overexpression of CD97 in Intestinal Epithelial Cells of Transgenic Mice Attenuates Colitis by Strengthening Adherens Junctions

Date Published: January 13, 2010 Publisher: Public Library of Science Author(s): Susann Becker, Elke Wandel, Manja Wobus, Rick Schneider, Salah Amasheh, Doreen Sittig, Christiane Kerner, Ronald Naumann, Joerg Hamann, Gabriela Aust, Stefan Bereswill. Abstract: The adhesion G-protein-coupled receptor CD97 is present in normal colonic enterocytes but overexpressed in colorectal carcinoma. To investigate the function of … Continue reading

Research Article: Glucocorticoid Receptor Localizes to Adherens Junctions at the Plasma Membrane of Keratinocytes

Date Published: April 30, 2013 Publisher: Public Library of Science Author(s): Olivera Stojadinovic, Andrew Sawaya, Irena Pastar, Marjana Tomic-Canic, David Holowka. Abstract: Glucocorticoids are important regulators of epidermal tissue homeostasis. As such, their clinical applications are widespread, ranging from inflammatory skin disorders to keloids and cancer. Glucocorticoids exert their effect by binding to glucocorticoid receptor … Continue reading

Research Article: Fibroblast Growth Factor Signaling Potentiates VE-Cadherin Stability at Adherens Junctions by Regulating SHP2

Date Published: May 22, 2012 Publisher: Public Library of Science Author(s): Kunihiko Hatanaka, Anthony A. Lanahan, Masahiro Murakami, Michael Simons, Masuko Ushio-Fukai. Abstract: The fibroblast growth factor (FGF) system plays a critical role in the maintenance of vascular integrity via enhancing the stability of VE-cadherin at adherens junctions. However, the precise molecular mechanism is not … Continue reading

Research Article: Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion

Date Published: November 6, 2012 Publisher: Public Library of Science Author(s): Doug A. Medvetz, Damir Khabibullin, Venkatesh Hariharan, Pat P. Ongusaha, Elena A. Goncharova, Tanja Schlechter, Thomas N. Darling, Ilse Hofmann, Vera P. Krymskaya, James K. Liao, Hayden Huang, Elizabeth P. Henske, Sang-Chul Nam. Abstract: Birt-Hogg-Dube (BHD) is a tumor suppressor gene syndrome associated with … Continue reading

Research Article: Mechanosensitive Adaptation of E-Cadherin Turnover across adherens Junctions

Date Published: June 5, 2015 Publisher: Public Library of Science Author(s): Simon de Beco, Jean-Baptiste Perney, Sylvie Coscoy, François Amblard, Cara Gottardi. Abstract: In the natural and technological world, multi-agent systems strongly depend on how the interactions are ruled between their individual components, and the proper control of time-scales and synchronization is a key … Continue reading

Research Article: PLEKHA7 Is an Adherens Junction Protein with a Tissue Distribution and Subcellular Localization Distinct from ZO-1 and E-Cadherin

Date Published: August 20, 2010 Publisher: Public Library of Science Author(s): Pamela Pulimeno, Christoph Bauer, Jeffrey Stutz, Sandra Citi, Robert Alan Arkowitz. Abstract: The pleckstrin-homology-domain-containing protein PLEKHA7 was recently identified as a protein linking the E-cadherin-p120 ctn complex to the microtubule cytoskeleton. Here we characterize the expression, tissue distribution and subcellular localization of PLEKHA7 by … Continue reading