Agrin | definition

  • a signal protein released between the synapse and a muscle cell by the developing neurite during synaptic formation


Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science.

Related Research

Research Article: Autoantibodies to Agrin in Myasthenia Gravis Patients

Date Published: March 14, 2014 Publisher: Public Library of Science Author(s): Bin Zhang, Chengyong Shen, Beverly Bealmear, Samia Ragheb, Wen-Cheng Xiong, Richard A. Lewis, Robert P. Lisak, Lin Mei, Mohammed Akaaboune. Abstract: To determine if patients with myasthenia gravis (MG) have antibodies to agrin, a proteoglycan released by motor neurons and is critical for … Continue reading

Research Article: Agrin Binds BMP2, BMP4 and TGFβ1

Date Published: May 21, 2010 Publisher: Public Library of Science Author(s): László Bányai, Peter Sonderegger, László Patthy, Bostjan Kobe. Abstract: The C-terminal 95 kDa fragment of some isoforms of vertebrate agrins is sufficient to induce clustering of acetylcholine receptors but despite two decades of intense agrin research very little is known about the function of … Continue reading

Research Article: Site Specific Cleavage Mediated by MMPs Regulates Function of Agrin

Date Published: September 11, 2012 Publisher: Public Library of Science Author(s): Trushar R. Patel, Georgina Butler, Ainsley McFarlane, Irene Xie, Christopher M. Overall, Jörg Stetefeld, Shu-min Duan. Abstract: Agrin is the key inducer of postsynaptic differentiations at the neuromuscular junction. The multidomain heparan sulfate proteoglycan is mediating via its N-terminal segment the interaction with laminin, … Continue reading

Research Article: The C-Terminal Fragment of Agrin (CAF), a Novel Marker of Renal Function, Is Filtered by the Kidney and Reabsorbed by the Proximal Tubule

Date Published: July 5, 2016 Publisher: Public Library of Science Author(s): Arezoo Daryadel, Monika Haubitz, Marta Figueiredo, Dominik Steubl, Marcel Roos, Armin Mäder, Stefan Hettwer, Carsten A. Wagner, Jeff M Sands. Abstract: Agrin, a multidomain proteoglycan and neurotrypsin, a neuronal serine protease, are important for forming (neuromuscular) synapses. Proteolytical activity of neurotrypsin produces a … Continue reading

Research Article: Agrin and Perlecan Mediate Tumorigenic Processes in Oral Squamous Cell Carcinoma

Date Published: December 15, 2014 Publisher: Public Library of Science Author(s): Rebeca Kawahara, Daniela C. Granato, Carolina M. Carnielli, Nilva K. Cervigne, Carine E. Oliveria, César A. R. Martinez, Sami Yokoo, Felipe P. Fonseca, Marcio Lopes, Alan R. Santos-Silva, Edgard Graner, Ricardo D. Coletta, Adriana Franco Paes Leme, Neil A. Hotchin. Abstract: Oral squamous … Continue reading

Research Article: Agrin and Synaptic Laminin Are Required to Maintain Adult Neuromuscular Junctions

Date Published: October 3, 2012 Publisher: Public Library of Science Author(s): Melanie A. Samuel, Gregorio Valdez, Juan C. Tapia, Jeff W. Lichtman, Joshua R. Sanes, Brian D. McCabe. Abstract: As synapses form and mature the synaptic partners produce organizing molecules that regulate each other’s differentiation and ensure precise apposition of pre- and post-synaptic specializations. At … Continue reading