AIRE (autoimmune regulator) | definition

  • a protein expressed by some epithelial cells in the thymus involved in exposing developing thymocytes to proteins of other organs to eliminate autoimmune diseases
  • a protein that educates immature T cells in the thymus not to attack the body’s normal tissues
By ProteinBoxBot at English Wikipedia – Transferred from en.wikipedia to Commons by Gonn., Public Domain,


Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science.


Related Research

Research Article: The AIRE -230Y Polymorphism Affects AIRE Transcriptional Activity: Potential Influence on AIRE Function in the Thymus

Date Published: May 15, 2015 Publisher: Public Library of Science Author(s): Thomas R. J. Lovewell, Andrew J. McDonagh, Andrew G. Messenger, Mimoun Azzouz, Rachid Tazi-Ahnini, Geraldo A. Passos. Abstract: The autoimmune regulator (AIRE) is expressed in the thymus, particularly in thymic medullary epithelial cells (mTECs), and is required for the ectopic expression of a … Continue reading

Research Article: Anti-Interferon Autoantibodies in Autoimmune Polyendocrinopathy Syndrome Type 1

Date Published: July 13, 2006 Publisher: Public Library of Science Author(s): Anthony Meager, Kumuthini Visvalingam, Pärt Peterson, Kaidi Möll, Astrid Murumägi, Kai Krohn, Petra Eskelin, Jaakko Perheentupa, Eystein Husebye, Yoshihisa Kadota, Nick Willcox, Ludvig Sollid Abstract: BackgroundThe autoimmune regulator (AIRE) gene influences thymic self-tolerance induction. In autoimmune polyendocrinopathy syndrome type 1 (APS1; OMIM 240300), recessive … Continue reading

Research Article: A Functional Alternative Splicing Mutation in AIRE Gene Causes Autoimmune Polyendocrine Syndrome Type 1

Date Published: January 8, 2013 Publisher: Public Library of Science Author(s): Junyu Zhang, Hongbin Liu, Zhiyuan Liu, Yong Liao, Luo Guo, Honglian Wang, Lin He, Xiaodong Zhang, Qinghe Xing, Tom R. Gaunt. Abstract: Autoimmune polyendocrine syndrome type 1 (APS-1) is a rare autosomal recessive disease defined by the presence of two of the three conditions: … Continue reading

Research Article: Identification of MiR-205 As a MicroRNA That Is Highly Expressed in Medullary Thymic Epithelial Cells

Date Published: August 13, 2015 Publisher: Public Library of Science Author(s): Imran S. Khan, Chong Y. Park, Anastasia Mavropoulos, Nikki Shariat, Joshua L. Pollack, Andrea J. Barczak, David J. Erle, Michael T. McManus, Mark S. Anderson, Lukas T. Jeker, Geraldo A Passos. Abstract: Thymic epithelial cells (TECs) support T cell development in the thymus. … Continue reading

Research Article: The Immune Response to Melanoma Is Limited by Thymic Selection of Self-Antigens

Date Published: April 10, 2012 Publisher: Public Library of Science Author(s): Ulrike Träger, Sophie Sierro, Gordana Djordjevic, Basma Bouzo, Shivani Khandwala, Antonella Meloni, Monika Mortensen, Anna Katharina Simon, Irun R. Cohen. Abstract: The expression of melanoma-associated antigens (MAA) being limited to normal melanocytes and melanomas, MAAs are ideal targets for immunotherapy and melanoma vaccines. As … Continue reading

Research Article: Autoimmune Gastro-Pancreatitis with Anti-Protein Disulfide Isomerase-Associated 2 Autoantibody in Aire-Deficient BALB/cAnN Mice

Date Published: August 26, 2013 Publisher: Public Library of Science Author(s): Hironori Kurisaki, Yukihiro Nagao, Seiho Nagafuchi, Masao Mitsuyama, Lucienne Chatenoud. Abstract: Although the autoimmune regulator (Aire) knockout (KO) mouse model has been reported to present various organ-specific autoimmune diseases depending on genetic background, autoimmune pancreatitis in mice of BALB/c background has not yet … Continue reading