Akt | definition

  • an enzyme involved in cell signaling related to growth and survival
  • also known as protein kinase B
Ribbon representation of the crystal structure of Akt-1-inhibitor complexes. By JianLi1989 – Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=16760153


Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science. http://www.garlandscience.com/


Related Research

Research Article: Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092

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Research Article: Inhibition of AKT with the Orally Active Allosteric AKT Inhibitor, MK-2206, Sensitizes Endometrial Cancer Cells to Progestin

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Research Article: Anti-Myeloma Activity of Akt Inhibition Is Linked to the Activation Status of PI3K/Akt and MEK/ERK Pathway

Date Published: November 21, 2012 Publisher: Public Library of Science Author(s): Vijay Ramakrishnan, Teresa Kimlinger, Jessica Haug, Utkarsh Painuly, Linda Wellik, Timothy Halling, S. Vincent Rajkumar, Shaji Kumar, Rakesh K. Srivastava. http://doi.org/10.1371/journal.pone.0050005 Abstract: The PI3K/Akt/mTOR signal transduction pathway plays a central role in multiple myeloma (MM) disease progression and development of therapeutic resistance. mTORC1 inhibitors have … Continue reading

Research Article: Intramolecular and Intermolecular Interactions of Protein Kinase B Define Its Activation In Vivo

Date Published: April 3, 2007 Publisher: Public Library of Science Author(s): Véronique Calleja, Damien Alcor, Michel Laguerre, Jongsun Park, Borivoj Vojnovic, Brian A Hemmings, Julian Downward, Peter J Parker, Banafshé Larijani, John Kuriyan Abstract: Protein kinase B (PKB/Akt) is a pivotal regulator of diverse metabolic, phenotypic, and antiapoptotic cellular controls and has been shown to … Continue reading