allosteric protein | definition

  • a protein that has at least two binding sites
  • a molecule that alters the activity of the protein at one site by the binding of ligand from another site
  • a protein involved in enzyme regulation
allosteric proteins
Allosteric regulation of an enzyme. By Tenthkrige (talk).Tenthkrige – Own work(Original text: I (Tenthkrige (talk)) created this work entirely by myself.), CC0, https://commons.wikimedia.org/w/index.php?curid=85816837

Source:

Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science. http://www.garlandscience.com/

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Research Article: Scalable Rule-Based Modelling of Allosteric Proteins and Biochemical Networks

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Research Article: Allosteric Communication Occurs via Networks of Tertiary and Quaternary Motions in Proteins

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Research Article: Structure of an Engineered β-Lactamase Maltose Binding Protein Fusion Protein: Insights into Heterotropic Allosteric Regulation

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Research Article: Exploiting Ligand-Protein Conjugates to Monitor Ligand-Receptor Interactions

Date Published: May 31, 2012 Publisher: Public Library of Science Author(s): Hirohito Haruki, Monica Rengifo Gonzalez, Kai Johnsson, Beata G. Vertessy. http://doi.org/10.1371/journal.pone.0037598 Abstract: We introduce three assays for analyzing ligand-receptor interactions based on the specific conjugation of ligands to SNAP-tag fusion proteins. Conjugation of ligands to different SNAP-tag fusions permits the validation of suspected interactions in … Continue reading