allosteric protein | definition

  • a protein that has at least two binding sites
  • a molecule that alters the activity of the protein at one site by the binding of ligand from another site
  • a protein involved in enzyme regulation
allosteric proteins
Allosteric regulation of an enzyme. By Tenthkrige (talk).Tenthkrige – Own work(Original text: I (Tenthkrige (talk)) created this work entirely by myself.), CC0,


Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science.


Related Research

Research Article: Computation of Conformational Coupling in Allosteric Proteins

Date Published: August 28, 2009 Publisher: Public Library of Science Author(s): Brian A. Kidd, David Baker, Wendy E. Thomas, Amnon Horovitz Abstract: In allosteric regulation, an effector molecule binding a protein at one site induces conformational changes, which alter structure and function at a distant active site. Two key challenges in the computational modeling of … Continue reading

Research Article: Scalable Rule-Based Modelling of Allosteric Proteins and Biochemical Networks

Date Published: November 4, 2010 Publisher: Public Library of Science Author(s): Julien F. Ollivier, Vahid Shahrezaei, Peter S. Swain, Rama Ranganathan Abstract: Much of the complexity of biochemical networks comes from the information-processing abilities of allosteric proteins, be they receptors, ion-channels, signalling molecules or transcription factors. An allosteric protein can be uniquely regulated by each … Continue reading

Research Article: Allosteric Communication Occurs via Networks of Tertiary and Quaternary Motions in Proteins

Date Published: February 20, 2009 Publisher: Public Library of Science Author(s): Michael D. Daily, Jeffrey J. Gray, Matthew P. Jacobson Abstract: Allosteric proteins bind an effector molecule at one site resulting in a functional change at a second site. We hypothesize that allosteric communication in proteins relies upon networks of quaternary (collective, rigid-body) and tertiary … Continue reading

Research Article: Structure of an Engineered β-Lactamase Maltose Binding Protein Fusion Protein: Insights into Heterotropic Allosteric Regulation

Date Published: June 14, 2012 Publisher: Public Library of Science Author(s): Wei Ke, Abigail H. Laurent, Morgan D. Armstrong, Yuchao Chen, William E. Smith, Jing Liang, Chapman M. Wright, Marc Ostermeier, Focco van den Akker, Bostjan Kobe. Abstract: Engineering novel allostery into existing proteins is a challenging endeavor to obtain novel sensors, therapeutic proteins, or … Continue reading

Research Article: Exploiting Ligand-Protein Conjugates to Monitor Ligand-Receptor Interactions

Date Published: May 31, 2012 Publisher: Public Library of Science Author(s): Hirohito Haruki, Monica Rengifo Gonzalez, Kai Johnsson, Beata G. Vertessy. Abstract: We introduce three assays for analyzing ligand-receptor interactions based on the specific conjugation of ligands to SNAP-tag fusion proteins. Conjugation of ligands to different SNAP-tag fusions permits the validation of suspected interactions in … Continue reading