allostery | definition

  • the change in protein’s structure by the binding of regulatory ligand or covalent modification which then alters the activity of the protein


Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science.


Related Research

Research Article: Allostery: An Overview of Its History, Concepts, Methods, and Applications

Date Published: June 2, 2016 Publisher: Public Library of Science Author(s): Jin Liu, Ruth Nussinov Abstract: The concept of allostery has evolved in the past century. In this Editorial, we briefly overview the history of allostery, from the pre-allostery nomenclature era starting with the Bohr effect (1904) to the birth of allostery by Monod and … Continue reading

Research Article: A Unified View of “How Allostery Works”

Date Published: February 6, 2014 Publisher: Public Library of Science Author(s): Chung-Jung Tsai, Ruth Nussinov, Dennis R. Livesay Abstract: The question of how allostery works was posed almost 50 years ago. Since then it has been the focus of much effort. This is for two reasons: first, the intellectual curiosity of basic science and the … Continue reading

Research Article: Rigid Residue Scan Simulations Systematically Reveal Residue Entropic Roles in Protein Allostery

Date Published: April 26, 2016 Publisher: Public Library of Science Author(s): Robert Kalescky, Hongyu Zhou, Jin Liu, Peng Tao, Dennis R Livesay Abstract: Intra-protein information is transmitted over distances via allosteric processes. This ubiquitous protein process allows for protein function changes due to ligand binding events. Understanding protein allostery is essential to understanding protein functions. … Continue reading

Research Article: Revealing Atomic-Level Mechanisms of Protein Allostery with Molecular Dynamics Simulations

Date Published: June 10, 2016 Publisher: Public Library of Science Author(s): Samuel Hertig, Naomi R. Latorraca, Ron O. Dror, Jin Liu Abstract: Molecular dynamics (MD) simulations have become a powerful and popular method for the study of protein allostery, the widespread phenomenon in which a stimulus at one site on a protein influences the properties … Continue reading

Research Article: Ack1: Activation and Regulation by Allostery

Date Published: January 14, 2013 Publisher: Public Library of Science Author(s): Ketan S. Gajiwala, Karen Maegley, RoseAnn Ferre, You-Ai He, Xiu Yu, Natarajan Kannan. Abstract: The non-receptor tyrosine kinase Ack1 belongs to a unique multi-domain protein kinase family, Ack. Ack is the only family of SH3 domain containing kinases to have an SH3 domain following … Continue reading