AMPA receptor | definition

  • also known as α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
  • a transmembrane glutamate-gated ion channel in the central nervous system responsible for excitatory membrane potential of the postsynaptic terminal
AMPA receptor. By Curtis Neveu – Own work, CC BY-SA 3.0,


Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science.


Related Research

Research Article: Perampanel Inhibition of AMPA Receptor Currents in Cultured Hippocampal Neurons

Date Published: September 17, 2014 Publisher: Public Library of Science Author(s): Chao-Yin Chen, Lucas Matt, Johannes Wilhelm Hell, Michael A. Rogawski, Jean-Pierre Mothet. Abstract: Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block … Continue reading

Research Article: Autoinactivation of the Stargazin–AMPA Receptor Complex: Subunit-Dependency and Independence from Physical Dissociation

Date Published: November 14, 2012 Publisher: Public Library of Science Author(s): Artur Semenov, Tommi Möykkynen, Sarah K. Coleman, Esa R. Korpi, Kari Keinänen, Zhe Zhang. Abstract: Agonist responses and channel kinetics of native α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are modulated by transmembrane accessory proteins. Stargazin, the prototypical accessory protein, decreases desensitization and increases agonist potency … Continue reading

Research Article: Ampa Receptor Subunit Expression in the Endoplasmic Reticulum in Frontal Cortex of Elderly Patients with Schizophrenia

Date Published: June 14, 2012 Publisher: Public Library of Science Author(s): John C. Hammond, James H. Meador-Woodruff, Vahram Haroutunian, Robert E. McCullumsmith, Thomas Burne. Abstract: Several lines of evidence indicate altered trafficking of α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptors in schizophrenia. Previous reports have shown potential changes in the trafficking of AMPA receptors based on subunit expression of … Continue reading

Research Article: AMPA Receptor Regulation at the mRNA and Protein Level in Rat Primary Cortical Cultures

Date Published: September 22, 2011 Publisher: Public Library of Science Author(s): Cesare Orlandi, Luca La Via, Daniela Bonini, Cristina Mora, Isabella Russo, Alessandro Barbon, Sergio Barlati, Stefan Maas. Abstract: Ionotropic glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are the major mediators of fast synaptic neurotransmission. In this work, we used primary cortical cultures from rats as … Continue reading

Research Article: Modulation of Glutamate Transport and Receptor Binding by Glutamate Receptor Antagonists in EAE Rat Brain

Date Published: November 26, 2014 Publisher: Public Library of Science Author(s): Grzegorz Sulkowski, Beata Dąbrowska-Bouta, Elżbieta Salińska, Lidia Strużyńska, Valentin Ceña. Abstract: The etiology of multiple sclerosis (MS) is currently unknown. However, one potential mechanism involved in the disease may be excitotoxicity. The elevation of glutamate in cerebrospinal fluid, as well as changes in … Continue reading

Research Article: Domain-Based Identification and Analysis of Glutamate Receptor Ion Channels and Their Relatives in Prokaryotes

Date Published: October 6, 2010 Publisher: Public Library of Science Author(s): Mao-Feng Ger, Gloria Rendon, Jeffrey L. Tilson, Eric Jakobsson, Robert Belshaw. Abstract: Voltage-gated and ligand-gated ion channels are used in eukaryotic organisms for the purpose of electrochemical signaling. There are prokaryotic homologues to major eukaryotic channels of these sorts, including voltage-gated sodium, potassium, and … Continue reading