anaphase-promoting complex | definition

  • also known as cyclosome or APC/C
  • a large protein complex which promotes ubiquitylation and destroys securin and cyclins
  • a protein that initiates the separation of sister chromatids leading to the transition of cell cycle stage from metaphase to anaphase during mitosis

Source:

Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science. http://www.garlandscience.com/

Advertisements
Advertisements

Related Research

Research Article: Building a pseudo-atomic model of the anaphase-promoting complex

Date Published: November 01, 2013 Publisher: International Union of Crystallography Author(s): Kiran Kulkarni, Ziguo Zhang, Leifu Chang, Jing Yang, Paula C. A. da Fonseca, David Barford. http://doi.org/10.1107/S0907444913018593 Abstract: This article describes an example of molecular replacement in which atomic models are used to interpret electron-density maps determined using single-particle electron-microscopy data. Partial Text   Source: … Continue reading

Research Article: Identification of Anaphase Promoting Complex Substrates in S. cerevisiae

Date Published: September 26, 2012 Publisher: Public Library of Science Author(s): Denis Ostapenko, Janet L. Burton, Mark J. Solomon, Michael Polymenis. http://doi.org/10.1371/journal.pone.0045895 Abstract: The Anaphase-Promoting Complex/Cyclosome (APC/C) is an essential ubiquitin ligase that targets numerous proteins for proteasome-mediated degradation in mitosis and G1. To gain further insight into cellular pathways controlled by APC/CCdh1, we developed two … Continue reading

Research Article: Cyclin A Degradation by Primate Cytomegalovirus Protein pUL21a Counters Its Innate Restriction of Virus Replication

Date Published: December 26, 2013 Publisher: Public Library of Science Author(s): Nicolas Caffarelli, Anthony R. Fehr, Dong Yu, William J. Britt. http://doi.org/10.1371/journal.ppat.1003825 Abstract: Cyclin A is critical for cellular DNA synthesis and S phase progression of the cell cycle. Human cytomegalovirus (HCMV) can reduce cyclin A levels and block cellular DNA synthesis, and cyclin A … Continue reading

Research Article: Nucleolar asymmetry and the importance of septin integrity upon cell cycle arrest

Date Published: March 24, 2017 Publisher: Public Library of Science Author(s): Urvashi Rai, Fadi Najm, Alan M. Tartakoff, Claude Prigent. http://doi.org/10.1371/journal.pone.0174306 Abstract: Cell cycle arrest can be imposed by inactivating the anaphase promoting complex (APC). In S. cerevisiae this arrest has been reported to stabilize a metaphase-like intermediate in which the nuclear envelope spans the … Continue reading