anaphase-promoting complex | definition

  • also known as cyclosome or APC/C
  • a large protein complex which promotes ubiquitylation and destroys securin and cyclins
  • a protein that initiates the separation of sister chromatids leading to the transition of cell cycle stage from metaphase to anaphase during mitosis


Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science.


Related Research

Research Article: Building a pseudo-atomic model of the anaphase-promoting complex

Date Published: November 01, 2013 Publisher: International Union of Crystallography Author(s): Kiran Kulkarni, Ziguo Zhang, Leifu Chang, Jing Yang, Paula C. A. da Fonseca, David Barford. Abstract: This article describes an example of molecular replacement in which atomic models are used to interpret electron-density maps determined using single-particle electron-microscopy data. Partial Text   Source: … Continue reading

Research Article: Identification of Anaphase Promoting Complex Substrates in S. cerevisiae

Date Published: September 26, 2012 Publisher: Public Library of Science Author(s): Denis Ostapenko, Janet L. Burton, Mark J. Solomon, Michael Polymenis. Abstract: The Anaphase-Promoting Complex/Cyclosome (APC/C) is an essential ubiquitin ligase that targets numerous proteins for proteasome-mediated degradation in mitosis and G1. To gain further insight into cellular pathways controlled by APC/CCdh1, we developed two … Continue reading

Research Article: Cyclin A Degradation by Primate Cytomegalovirus Protein pUL21a Counters Its Innate Restriction of Virus Replication

Date Published: December 26, 2013 Publisher: Public Library of Science Author(s): Nicolas Caffarelli, Anthony R. Fehr, Dong Yu, William J. Britt. Abstract: Cyclin A is critical for cellular DNA synthesis and S phase progression of the cell cycle. Human cytomegalovirus (HCMV) can reduce cyclin A levels and block cellular DNA synthesis, and cyclin A … Continue reading

Research Article: Nucleolar asymmetry and the importance of septin integrity upon cell cycle arrest

Date Published: March 24, 2017 Publisher: Public Library of Science Author(s): Urvashi Rai, Fadi Najm, Alan M. Tartakoff, Claude Prigent. Abstract: Cell cycle arrest can be imposed by inactivating the anaphase promoting complex (APC). In S. cerevisiae this arrest has been reported to stabilize a metaphase-like intermediate in which the nuclear envelope spans the … Continue reading