anchorage dependence | definition

  • dependence of cell growth, spread, and survival on attachment to an underlying layer
anchorage dependence
Pearson Education.


Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science.


Related Research

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Date Published: July 26, 2010 Publisher: Public Library of Science Author(s): Davide Danovi, Catherine A. Cremona, Gisela Machado-da-Silva, Sreya Basu, Luke A. Noon, Simona Parrinello, Alison C. Lloyd, Neil A. Hotchin. Abstract: Anchorage-independent proliferation is a hallmark of oncogenic transformation and is thought to be conducive to proliferation of cancer cells away from their site … Continue reading

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Date Published: August 23, 2011 Publisher: Public Library of Science Author(s): Priya Prakash Karmali, Chris Brunquell, Hau Tram, Shubha Kale Ireland, Erkki Ruoslahti, Hector Biliran, Guenter Schneider. Abstract: Resistance to anoikis, which is defined as apoptosis induced by loss of integrin-mediated cell attachment to the extracellular matrix, is a determinant of tumor progression and metastasis. … Continue reading

Research Article: The Anoikis Effector Bit1 Displays Tumor Suppressive Function in Lung Cancer Cells

Date Published: July 8, 2014 Publisher: Public Library of Science Author(s): Xin Yao, Scott Jennings, Shubha Kale Ireland, Tri Pham, Brandi Temple, Mya Davis, Renwei Chen, Ian Davenport, Hector Biliran, Lucia R. Languino. Abstract: The mitochondrial Bit1 (Bcl-2 inhibitor of transcription 1) protein is a part of an apoptotic pathway that is uniquely regulated … Continue reading

Research Article: iRFP Is a Real Time Marker for Transformation Based Assays in High Content Screening

Date Published: June 2, 2014 Publisher: Public Library of Science Author(s): Viola Paulus-Hock, Eric C. Cheung, Patricia Roxburgh, Karen H. Vousden, Andreas K. Hock, Mark Jackson. Abstract: Anchorage independent growth is one of the hallmarks of oncogenic transformation. Here we show that infrared fluorescent protein (iRFP) based assays allow accurate and unbiased determination of … Continue reading

Related External Links

Advances in cell culture: anchorage dependence

Competitive nuclear export of cyclin D1 and Hic-5 regulates anchorage dependence of cell growth and survival