antigenic variation | definition

  • property of a pathogen that enables them to evade the adaptive immune system by changing the antigens on its surface


Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science.


Related Research

Research Article: Mosaic VSGs and the Scale of Trypanosoma brucei Antigenic Variation

Date Published: July 11, 2013 Publisher: Public Library of Science Author(s): James P. J. Hall, Huanhuan Wang, J. David Barry, David Horn. Abstrac:t A main determinant of prolonged Trypanosoma brucei infection and transmission and success of the parasite is the interplay between host acquired immunity and antigenic variation of the parasite variant surface glycoprotein … Continue reading

Research Article: The Use of High-Throughput DNA Sequencing in the Investigation of Antigenic Variation: Application to Neisseria Species

Date Published: January 22, 2014 Publisher: Public Library of Science Author(s): John K. Davies, Paul F. Harrison, Ya-Hsun Lin, Stephanie Bartley, Chen Ai Khoo, Torsten Seemann, Catherine S. Ryan, Charlene M. Kahler, Stuart A. Hill, Thomas Rudel. Abstract: Antigenic variation occurs in a broad range of species. This process resembles gene conversion in that … Continue reading

Research Article: A Histone Methyltransferase Modulates Antigenic Variation in African Trypanosomes

Date Published: July 1, 2008 Publisher: Public Library of Science Author(s): Luisa M Figueiredo, Christian J Janzen, George A.M Cross, Keith Gull Abstract: To evade the host immune system, several pathogens periodically change their cell-surface epitopes. In the African trypanosomes, antigenic variation is achieved by tightly regulating the expression of a multigene family encoding a … Continue reading

Research Article: DNA Break Site at Fragile Subtelomeres Determines Probability and Mechanism of Antigenic Variation in African Trypanosomes

Date Published: March 28, 2013 Publisher: Public Library of Science Author(s): Lucy Glover, Sam Alsford, David Horn, Kent L. Hill. Abstract: Antigenic variation in African trypanosomes requires monoallelic transcription and switching of variant surface glycoprotein (VSG) genes. The transcribed VSG, always flanked by ‘70 bp’-repeats and telomeric-repeats, is either replaced through DNA double-strand break … Continue reading