antiparallel (genetics) | definition

  • the relative orientation of the two strands in DNA where the leading strand is replicated in one direction while the lagging strand is replicated in the other direction
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Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science.


Related Research

Research Article: Structural Aspects of the Antiparallel and Parallel Duplexes Formed by DNA, 2’-O-Methyl RNA and RNA Oligonucleotides

Date Published: November 18, 2015 Publisher: Public Library of Science Author(s): Marta Szabat, Tomasz Pedzinski, Tomasz Czapik, Elzbieta Kierzek, Ryszard Kierzek, Rakesh N. Veedu. Abstract: This study investigated the influence of the nature of oligonucleotides on the abilities to form antiparallel and parallel duplexes. Base pairing of homopurine DNA, 2’-O-MeRNA and RNA oligonucleotides with … Continue reading

Research Article: Increasing the Analytical Sensitivity by Oligonucleotides Modified with Para- and Ortho-Twisted Intercalating Nucleic Acids – TINA

Date Published: June 3, 2011 Publisher: Public Library of Science Author(s): Uffe V. Schneider, Imrich Géci, Nina Jøhnk, Nikolaj D. Mikkelsen, Erik B. Pedersen, Gorm Lisby, Meni Wanunu. Abstract: The sensitivity and specificity of clinical diagnostic assays using DNA hybridization techniques are limited by the dissociation of double-stranded DNA (dsDNA) antiparallel duplex helices. This situation … Continue reading

Research Article: Targeting Human Telomeric G-Quadruplex DNA and Inhibition of Telomerase Activity With [(dmb)2Ru(obip)Ru(dmb)2]4+

Date Published: December 27, 2013 Publisher: Public Library of Science Author(s): Shuo Shi, Shane Gao, Tongcheng Cao, Jie Liu, Xing Gao, Jian Hao, Chunyan Lv, Hailiang Huang, Jun Xu, Tianming Yao, Andrea Cavalli. Abstract: Inhibition of telomerase by inducing/stabilizing G-quadruplex formation is a promising strategy to design new anticancer drugs. We synthesized and characterized … Continue reading

DNA Double-Helix Structure

OpenStax Biology 2e. DNA has a double-helix structure. The sugar and phosphate lie on the outside of the helix, forming the DNA’s backbone. The nitrogenous bases are stacked in the interior, like a pair of staircase steps. Hydrogen bonds bind the pairs to each other. Every base pair in the double helix is separated from … Continue reading