Apaf1 | definition

  • also known as apoptotic protease activating factor 1
  • protein involved in the intrinsic apoptotic pathway which forms into apoptosome after binding with cytochrome c
Structure of Apaf1 protein. By Ismaïl Jarmouni – Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=86144499


Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science. http://www.garlandscience.com/


Related Research

Research Article: Altered Mitochondria Morphology and Cell Metabolism in Apaf1-Deficient Cells

Date Published: January 9, 2014 Publisher: Public Library of Science Author(s): Mónica Sancho, Anna Gortat, Andrés E. Herrera, Vicente Andreu-Fernández, Elisabetta Ferraro, Francesco Cecconi, Mar Orzáez, Enrique Pérez-Payá, Dhyan Chandra. http://doi.org/10.1371/journal.pone.0084666 Abstract: Apaf1 (apoptotic protease activating factor 1) is the central component of the apoptosome, a multiprotein complex that activates procaspase-9 after cytochrome c release … Continue reading

Research Article: Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells

Date Published: March 29, 2018 Publisher: Public Library of Science Author(s): Honglian Tong, Yasunobu Miyake, Fumika Mi-ichi, Yoichiro Iwakura, Hiromitsu Hara, Hiroki Yoshida, Shawn B. Bratton. http://doi.org/10.1371/journal.pone.0195119 Abstract: Apaf1 is a critical component of the apoptosome and initiates apoptosis downstream mitochondrial damages. Although the importance of Apaf1 in embryonic development was shown, the role of … Continue reading

Research Article: The Apoptotic Function Analysis of p53, Apaf1, Caspase3 and Caspase7 during the Spermatogenesis of the Chinese Fire-Bellied Newt Cynops orientalis

Date Published: June 29, 2012 Publisher: Public Library of Science Author(s): Da-Hui Wang, Jian-Rao Hu, Li-Ya Wang, Yan-Jun Hu, Fu-Qing Tan, Hong Zhou, Jian-Zhong Shao, Wan-Xi Yang, Sue Cotterill. http://doi.org/10.1371/journal.pone.0039920 Abstract: Spontaneous and stress-induced germ cell apoptosis during spermatogenesis of multicellular organisms have been investigated broadly in mammals. Spermatogenetic process in urodele amphibians was essentially like … Continue reading

Research Article: The structure of XIAP BIR2: understanding the selectivity of the BIR domains

Date Published: September 01, 2013 Publisher: International Union of Crystallography Author(s): Christine Lukacs, Charles Belunis, Robert Crowther, Waleed Danho, Lin Gao, Barry Goggin, Cheryl A. Janson, Shirley Li, Stacy Remiszewski, Andrew Schutt, Manish K. Thakur, Saroj K. Singh, Srinivasan Swaminathan, Rajat Pandey, Rajiv Tyagi, Ramachandraiah Gosu, Ajith V. Kamath, Andreas Kuglstatter. http://doi.org/10.1107/S0907444913016284 Abstract: The high-resolution … Continue reading