arrestin | definition

  • protein that desensitize the G-protein coupled receptor
  • prevents G proteins to interact with the G-protein coupled receptor
  • serves as an adaptor to couple the G-protein coupled receptor to clathrin-dependent endocytosis


Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science.


Related Research

Research Article: Distinct and Shared Roles of β-Arrestin-1 and β-Arrestin-2 on the Regulation of C3a Receptor Signaling in Human Mast Cells

Date Published: May 12, 2011 Publisher: Public Library of Science Author(s): Arpana Vibhuti, Kshitij Gupta, Hariharan Subramanian, Qiang Guo, Hydar Ali, Karl-Wilhelm Koch. Abstract: The complement component C3a induces degranulation in human mast cells via the activation of cell surface G protein coupled receptors (GPCR; C3aR). For most GPCRs, agonist-induced receptor phosphorylation leads to the … Continue reading

Research Article: β-Arrestin-Dependent Deactivation of Mouse Melanopsin

Date Published: November 17, 2014 Publisher: Public Library of Science Author(s): Evan G. Cameron, Phyllis R. Robinson, Cheryl M. Craft. Abstract: In mammals, the expression of the unusual visual pigment, melanopsin, is restricted to a small subset of intrinsically photosensitive retinal ganglion cells (ipRGCs), whose signaling regulate numerous non-visual functions including sleep, circadian photoentrainment … Continue reading

Research Article: FYVE-Dependent Endosomal Targeting of an Arrestin-Related Protein in Amoeba

Date Published: December 13, 2010 Publisher: Public Library of Science Author(s): Dorian Guetta, Karine Langou, Didier Grunwald, Gérard Klein, Laurence Aubry, Diane Bassham. Abstract: Visual and β-arrestins are scaffolding proteins involved in the regulation of receptor-dependent intracellular signaling and their trafficking. The arrestin superfamilly includes several arrestin domain-containing proteins and the structurally related protein Vps26. … Continue reading

Research Article: Distinct Cellular and Subcellular Distributions of G Protein-Coupled Receptor Kinase and Arrestin Isoforms in the Striatum

Date Published: November 6, 2012 Publisher: Public Library of Science Author(s): Evgeny Bychkov, Lilia Zurkovsky, Mika B. Garret, Mohamed R. Ahmed, Eugenia V. Gurevich, Veronique Sgambato-Faure. Abstract: G protein-coupled receptor kinases (GRKs) and arrestins mediate desensitization of G protein-coupled receptors (GPCR). Arrestins also mediate G protein-independent signaling via GPCRs. Since GRK and arrestins demonstrate no … Continue reading

Research Article: Mammalian Alpha Arrestins Link Activated Seven Transmembrane Receptors to Nedd4 Family E3 Ubiquitin Ligases and Interact with Beta Arrestins

Date Published: December 7, 2012 Publisher: Public Library of Science Author(s): Fortune F. Shea, Jennie L. Rowell, Yechaowei Li, Tien-Hsien Chang, Carlos E. Alvarez, Robert E. Means. Abstract: The complement of fungal cell surface proteins is widely regulated by ubiquitination of membrane proteins, which results in their endocytosis and vacuolar degradation. For diverse fungal transporters, … Continue reading