autophagosome | definition

an organelle enclosed by a double membrane and contains cytoplasmic contents that will undergo degradation


Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science.


Related Research

Research Article: Proteomic Profiling of Autophagosome Cargo in Saccharomyces cerevisiae

Date Published: March 13, 2014 Publisher: Public Library of Science Author(s): Kuninori Suzuki, Shingo Nakamura, Mayumi Morimoto, Kiyonaga Fujii, Nobuo N. Noda, Fuyuhiko Inagaki, Yoshinori Ohsumi, Matthew Seaman. Abstract: Macroautophagy (autophagy) is a bulk protein-degradation system ubiquitously conserved in eukaryotic cells. During autophagy, cytoplasmic components are enclosed in a membrane compartment, called an autophagosome. … Continue reading

Research Article: Regulators of Autophagosome Formation in Drosophila Muscles

Date Published: February 18, 2015 Publisher: Public Library of Science Author(s): Jonathan Zirin, Joppe Nieuwenhuis, Anastasia Samsonova, Rong Tao, Norbert Perrimon, Eric Baehrecke Abstract: Given the diversity of autophagy targets and regulation, it is important to characterize autophagy in various cell types and conditions. We used a primary myocyte cell culture system to assay the … Continue reading

Research Article: HCV Induces the Expression of Rubicon and UVRAG to Temporally Regulate the Maturation of Autophagosomes and Viral Replication

Date Published: March 25, 2015 Publisher: Public Library of Science Author(s): Linya Wang, Yongjun Tian, Jing-hsiung James Ou, Guangxiang George Luo. Abstract: Hepatitis C virus (HCV) induces autophagy to enhance its replication. However, how HCV regulates the autophagic pathway remains largely unclear. In this report, we demonstrated that HCV infection could induce the expression … Continue reading

Research Article: HCV-induced autophagosomes are generated via homotypic fusion of phagophores that mediate HCV RNA replication

Date Published: September 19, 2017 Publisher: Public Library of Science Author(s): Linya Wang, Ja Yeon Kim, Helene Minyi Liu, Michael M. C. Lai, Jing-hsiung James Ou, Aleem Siddiqui. Abstract: Hepatitis C virus (HCV) induces autophagy to promote its replication, including its RNA replication, which can take place on double-membrane vesicles known as autophagosomes. However, … Continue reading