autophagy | definition

the process of digesting worn-out cellular components by the cell’s own lysosomes


Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science.


Related Research

Research Article: Characterization of the Autophagy Marker Protein Atg8 Reveals Atypical Features of Autophagy in Plasmodium falciparum

Date Published: November 26, 2014 Publisher: Public Library of Science Author(s): Rahul Navale, Aparna Devi Allanki, Puran Singh Sijwali, Volker Theo Heussler. Abstract: Conventional autophagy is a lysosome-dependent degradation process that has crucial homeostatic and regulatory functions in eukaryotic organisms. As malaria parasites must dispose a number of self and host cellular contents, we … Continue reading

Research Article: Autophagy in Idiopathic Pulmonary Fibrosis

Date Published: July 18, 2012 Publisher: Public Library of Science Author(s): Avignat S. Patel, Ling Lin, Alexander Geyer, Jeffrey A. Haspel, Chang Hyeok An, Jiaofei Cao, Ivan O. Rosas, Danielle Morse, Oliver Eickelberg. Abstract: Autophagy is a basic cellular homeostatic process important to cell fate decisions under conditions of stress. Dysregulation of autophagy impacts numerous … Continue reading

Research Article: Multiple Roles of the Cytoskeleton in Bacterial Autophagy

Date Published: November 20, 2014 Publisher: Public Library of Science Author(s): Serge Mostowy, Virginia Miller. Abstract: Partial Text Several bacterial pathogens are targeted by macroautophagy (referred to as autophagy hereafter), and autophagy is widely recognized as an important antibacterial defence mechanism [1]. On the other hand, new work has shown that some bacterial pathogens … Continue reading

Research Article: The Contribution of Lysosomotropism to Autophagy Perturbation

Date Published: November 22, 2013 Publisher: Public Library of Science Author(s): Roshan Ashoor, Rolla Yafawi, Bart Jessen, Shuyan Lu, Srinivasa M Srinivasula. Abstract: Autophagy refers to the catabolic process in eukaryotic cells that delivers cytoplasmic material to lysosomes for degradation. This highly conserved process is involved in the clearance of long-lived proteins and damaged organelles. … Continue reading

Research Article: Lysosome Transport as a Function of Lysosome Diameter

Date Published: January 31, 2014 Publisher: Public Library of Science Author(s): Debjyoti Bandyopadhyay, Austin Cyphersmith, Jairo A. Zapata, Y. Joseph Kim, Christine K. Payne, Xiaochen Wang. Abstract: Lysosomes are membrane-bound organelles responsible for the transport and degradation of intracellular and extracellular cargo. The intracellular motion of lysosomes is both diffusive and active, mediated by … Continue reading

Research Article: Inhibition of Glioma Cell Lysosome Exocytosis Inhibits Glioma Invasion

Date Published: September 28, 2012 Publisher: Public Library of Science Author(s): Yu Liu, Yijiang Zhou, Keqing Zhu, Guillermo Velasco. Abstract: Cancer cells invade by secreting enzymes that degrade the extracellular matrix and these are sequestered in lysosomal vesicles. In this study, the effects of the selective lysosome lysing drug GPN and the lysosome exocytosis inhibitor … Continue reading