Bak | definition


Related Posts:

  • a mammalian effector protein of the intrinsic pathway of apoptosis
  • a protein found in the mitochondrial outer membrane that induces apoptosis even in the absence of apoptotic signal


Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raf, M., Roberts, K., & Walter, P. (2015). Molecular Biology of the Cell. New York: Garland Science.


Related Research

Research Article: Translocation of a Bak C-Terminus Mutant from Cytosol to Mitochondria to Mediate Cytochrome c Release: Implications for Bak and Bax Apoptotic Function

Date Published: March 19, 2012 Publisher: Public Library of Science Author(s): Pedro Eitz Ferrer, Paul Frederick, Jacqueline M. Gulbis, Grant Dewson, Ruth M. Kluck, Andrei L. Gartel. Abstract: One of two proapoptotic Bcl-2 proteins, Bak or Bax, is required to permeabilize the mitochondrial outer membrane during apoptosis. While Bax is mostly cytosolic and translocates to … Continue reading

Research Article: A BAX/BAK and Cyclophilin D-Independent Intrinsic Apoptosis Pathway

Date Published: June 12, 2012 Publisher: Public Library of Science Author(s): Sebastián Zamorano, Diego Rojas-Rivera, Fernanda Lisbona, Valentina Parra, Felipe A. Court, Rosario Villegas, Emily H. Cheng, Stanley J. Korsmeyer, Sergio Lavandero, Claudio Hetz, Dhyan Chandra. Abstract: Most intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the … Continue reading

Research Article: Blockade of the BAK Hydrophobic Groove by Inhibitory Phosphorylation Regulates Commitment to Apoptosis

Date Published: November 26, 2012 Publisher: Public Library of Science Author(s): Abul Azad, Joanna Fox, Sabrina Leverrier, Alan Storey, Boris Zhivotovsky. Abstract: The BCL-2 family protein BAK is a key regulator of mitochondrial apoptosis. BAK activation first involves N-terminal conformational changes that lead to the transient exposure of the BAK BH3 domain that then inserts … Continue reading

Research Article: Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins

Date Published: November 2, 2016 Publisher: Public Library of Science Author(s): Katharine J. Goodall, Megan L. Finch-Edmondson, Joanne van Vuuren, George C. Yeoh, Ian E. Gentle, James E. Vince, Paul G. Ekert, David L. Vaux, Bernard A. Callus, Dhyan Chandra. Abstract: Apoptosis mediated by Bax or Bak is usually thought to be triggered by … Continue reading