calcitonin | definition

hormone produced by the parafollicular cells of the thyroid gland that functions to lower blood Ca2+ levels and promote bone growth


Source:

Clark, M., Douglas, M., Choi, J. Biology 2e. Houston, Texas: OpenStax. Access for free at: https://openstax.org/details/books/biology-2e

Advertisements
Advertisements

Research Article: Calcitonin Receptor-Zonula Occludens-1 Interaction Is Critical for Calcitonin-Stimulated Prostate Cancer Metastasis

Date Published: March 2, 2016 Publisher: Public Library of Science Author(s): Ahmed Aljameeli, Arvind Thakkar, Shibu Thomas, Vijaybasker Lakshmikanthan, Kenneth A. Iczkowski, Girish V. Shah, Natasha Kyprianou. http://doi.org/10.1371/journal.pone.0150090 Abstract: The role of neuroendocrine peptide calcitonin (CT) and its receptor (CTR) in epithelial cancer progression is an emerging concept with great clinical potential. Expression of CT … Continue reading

Research Article: Prolonged Calcitonin Receptor Signaling by Salmon, but Not Human Calcitonin, Reveals Ligand Bias

Date Published: March 18, 2014 Publisher: Public Library of Science Author(s): Kim Vietz Andreassen, Sara Toftegaard Hjuler, Sebastian G. Furness, Patrick M. Sexton, Arthur Christopoulos, Olivier Nosjean, Morten Asser Karsdal, Kim Henriksen, Roland Seifert. http://doi.org/10.1371/journal.pone.0092042 Abstract: Salmon calcitonin (sCT) and human calcitonin (hCT) are pharmacologically distinct. However, the reason for the differences is unclear. Here … Continue reading

Research Article: Heterodimerization of the prostaglandin E2 receptor EP2 and the calcitonin receptor CTR

Date Published: November 2, 2017 Publisher: Public Library of Science Author(s): Shin Matsubara, Akira Shiraishi, Tsubasa Sakai, Toshimi Okuda, Honoo Satake, Arun Shukla. http://doi.org/10.1371/journal.pone.0187711 Abstract: G protein-coupled receptors (GPCRs) have been found to form heterodimers and modulate or fine-tune the functions of GPCRs. However, the involvement of GPCR heterodimerization and its functional consequences in gonadal … Continue reading

Research Article: Heterodimerization of the prostaglandin E2 receptor EP2 and the calcitonin receptor CTR

Date Published: November 2, 2017 Publisher: Public Library of Science Author(s): Shin Matsubara, Akira Shiraishi, Tsubasa Sakai, Toshimi Okuda, Honoo Satake, Arun Shukla. http://doi.org/10.1371/journal.pone.0187711 Abstract: G protein-coupled receptors (GPCRs) have been found to form heterodimers and modulate or fine-tune the functions of GPCRs. However, the involvement of GPCR heterodimerization and its functional consequences in gonadal … Continue reading

Research Article: Role of Calcitonin Gene-Related Peptide in Functional Adaptation of the Skeleton

Date Published: December 23, 2014 Publisher: Public Library of Science Author(s): Susannah J. Sample, Caitlin M. Heaton, Mary Behan, Jason A. Bleedorn, Molly A. Racette, Zhengling Hao, Peter Muir, Ryan K. Roeder. http://doi.org/10.1371/journal.pone.0113959 Abstract: Peptidergic sensory nerve fibers innervating bone and periosteum are rich in calcitonin gene-related peptide (CGRP), an osteoanabolic neurotransmitter. There are two … Continue reading

Research Article: Calcitonin Peptide Family Members Are Differentially Regulated by LPS and Inhibit Functions of Rat Alveolar NR8383 Macrophages

Date Published: October 13, 2016 Publisher: Public Library of Science Author(s): Aichurek Soultanova, Zbigniew Mikulski, Uwe Pfeil, Veronika Grau, Wolfgang Kummer, James Porter. http://doi.org/10.1371/journal.pone.0163483 Abstract: Members of the calcitonin peptide family—calcitonin gene-related peptide (CGRP), adrenomedullin (AM), and adrenomedullin2/intermedin (IMD)–exert modulatory effects upon monocytes and macrophages of various extrapulmonary origins. Utilizing the rat alveolar macrophage (AMφ) … Continue reading

Research Article: Superior Cervical Ganglia Neurons Induce Foxp3+ Regulatory T Cells via Calcitonin Gene-Related Peptide

Date Published: March 29, 2016 Publisher: Public Library of Science Author(s): Kirsten Szklany, Evelyn Ruiter, Firoz Mian, Wolfgang Kunze, John Bienenstock, Paul Forsythe, Khalil Karimi, Hossam M Ashour. http://doi.org/10.1371/journal.pone.0152443 Abstract: The nervous and immune systems communicate bidirectionally, utilizing diverse molecular signals including cytokines and neurotransmitters to provide an integrated response to changes in the body’s … Continue reading

Research Article: Calcitonin Gene-Related Peptide Modulates Heat Nociception in the Human Brain – An fMRI Study in Healthy Volunteers

Date Published: March 18, 2016 Publisher: Public Library of Science Author(s): Mohammad Sohail Asghar, Lino Becerra, Henrik B. W. Larsson, David Borsook, Messoud Ashina, James Porter. http://doi.org/10.1371/journal.pone.0150334 Abstract: Intravenous infusion of calcitonin-gene-related-peptide (CGRP) provokes headache and migraine in humans. Mechanisms underlying CGRP-induced headache are not fully clarified and it is unknown to what extent CGRP … Continue reading

Research Article: Calcitonin Gene-Related Peptide (CGRP) Receptors Are Important to Maintain Cerebrovascular Reactivity in Chronic Hypertension

Date Published: April 10, 2015 Publisher: Public Library of Science Author(s): Zhenghui Wang, Belén Cantó Martorell, Thomas Wälchli, Olga Vogel, Jan Fischer, Walter Born, Johannes Vogel, James Porter. http://doi.org/10.1371/journal.pone.0123697 Abstract: Cerebral blood flow autoregulation (CA) shifts to higher blood pressures in chronic hypertensive patients, which increases their risk for brain damage. Although cerebral vascular smooth … Continue reading

Research Article: Heat Hyperalgesia and Mechanical Hypersensitivity Induced by Calcitonin Gene-Related Peptide in a Mouse Model of Neurofibromatosis

Date Published: September 3, 2014 Publisher: Public Library of Science Author(s): Stephanie White, Blanca Marquez de Prado, Andrew F. Russo, Donna L. Hammond, Claudia Sommer. http://doi.org/10.1371/journal.pone.0106767 Abstract: This study examined whether mice with a deficiency of neurofibromin, a Ras GTPase activating protein, exhibit a nociceptive phenotype and probed a possible contribution by calcitonin gene-related peptide. … Continue reading

Advertisements
Advertisements