Equilibrium and Metabolism (Campbell Biology)
Reactions in an isolated system eventually reach equilibrium and can then do no work. The chemical reactions of metabolism are reversible, and they, too, would reach equilibrium if they occurred in the isolation of a test tube. Because systems at equilibrium are at a minimum of G and can do no work, a cell that has reached metabolic equilibrium is dead! The fact that metabolism as a whole is never at equilibrium is one of the defining features of life.
Like most systems, a living cell is not in equilibrium. The constant flow of materials in and out of the cell keeps the metabolic pathways from ever reaching equilibrium, and the cell continues to do work throughout its life. This principle is illustrated by the open (and more realistic) hydroelectric system. However, unlike this simple system in which water flowing downhill turns a single turbine, a catabolic pathway in a cell releases free energy in a series of reactions. An example is cellular respiration, illustrated by analogy. Some of the reversible reactions of respiration are constantly “pulled” in one direction—that is, they are kept out of equilibrium. The key to maintaining this lack of equilibrium is that the product of a reaction does not accumulate but instead becomes a reactant in the next step; finally, waste products are expelled from the cell. The overall sequence of reactions is kept going by the huge free-energy difference between glucose and oxygen at the top of the energy “hill” and carbon dioxide and water at the “downhill” end. As long as our cells have a steady supply of glucose or other fuels and oxygen and are able to expel waste products to the surroundings, their metabolic pathways never reach equilibrium and can continue to do the work of life.
Stepping back to look at the big picture, we can see once again how important it is to think of organisms as open systems. Sunlight provides a daily source of free energy for an ecosystem’s plants and other photosynthetic organisms. Animals and other non-photosynthetic organisms in an ecosystem must have a source of free energy in the form of the organic products of photosynthesis. Now that we have applied the free-energy concept to metabolism, we are ready to see how a cell actually performs the work of life.
Urry, Lisa A.. Campbell Biology. Pearson Education. Kindle Edition. https://www.pearson.com/us/higher-education/series/Campbell-Biology-Series/2244849.html
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Research Article: Application of Equilibrium Models of Solution Hybridization to Microarray Design and Analysis
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Research Article: Analysis of equilibrium binding of an orthosteric tracer and two allosteric modulators
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