erythropoietin (EPO) | definition

hormone produced by the kidneys to stimulate red blood cell production in the bone marrow


Clark, M., Douglas, M., Choi, J. Biology 2e. Houston, Texas: OpenStax. Access for free at:


Research Article: Prognostic Significance of Erythropoietin in Pancreatic Adenocarcinoma

Date Published: August 1, 2011 Publisher: Public Library of Science Author(s): Thilo Welsch, Stefanie Zschäbitz, Verena Becker, Thomas Giese, Frank Bergmann, Ulf Hinz, Shereen Keleg, Anette Heller, Bence Sipos, Ursula Klingmüller, Markus W. Büchler, Jens Werner, Nathalia A. Giese, S. K. Batra. Abstract: Erythropoietin (Epo) administration has been reported to have tumor-promoting effects in anemic … Continue reading

Research Article: Erythropoietin Couples Hematopoiesis with Bone Formation

Date Published: May 27, 2010 Publisher: Public Library of Science Author(s): Yusuke Shiozawa, Younghun Jung, Anne M. Ziegler, Elisabeth A. Pedersen, Jianhua Wang, Zhuo Wang, Junhui Song, Jingcheng Wang, Clara H. Lee, Sudha Sud, Kenneth J. Pienta, Paul H. Krebsbach, Russell S. Taichman, Raquel Gonçalves. Abstract: It is well established that bleeding activates the hematopoietic … Continue reading

Research Article: Recombinant Erythropoietin in Humans Has a Prolonged Effect on Circulating Erythropoietin Isoform Distribution

Date Published: October 21, 2014 Publisher: Public Library of Science Author(s): Niels Jacob Aachmann-Andersen, Søren Just Christensen, Kristian Lisbjerg, Peter Oturai, Anne-Kristine Meinild-Lundby, Niels-Henrik Holstein-Rathlou, Carsten Lundby, Niels Vidiendal Olsen, Kathleen Freson. Abstract: The membrane-assisted isoform immunoassay (MAIIA) quantitates erythropoietin (EPO) isoforms as percentages of migrated isoforms (PMI). We evaluated the effect of recombinant … Continue reading

Research Article: The Erythropoietin/Erythropoietin Receptor Signaling Pathway Promotes Growth and Invasion Abilities in Human Renal Carcinoma Cells

Date Published: September 18, 2012 Publisher: Public Library of Science Author(s): Pengjie Wu, Ning Zhang, Xi Wang, Chi Zhang, Teng Li, Xianghui Ning, Kan Gong, Karl X. Chai. Abstract: Co-expression of erythropoietin (Epo) and erythropoietin receptor (EpoR) has been found in various non-hematopoietic cancers including hereditary and sporadic renal cell carcinomas (RCC), but the Epo/EpoR … Continue reading

Research Article: Soluble Erythropoietin Receptor Contributes to Erythropoietin Resistance in End-Stage Renal Disease

Date Published: February 16, 2010 Publisher: Public Library of Science Author(s): Eliyahu V. Khankin, Walter P. Mutter, Hector Tamez, Hai-Tao Yuan, S. Ananth Karumanchi, Ravi Thadhani, Vineet Gupta. Abstract: Erythropoietin is a growth factor commonly used to manage anemia in patients with chronic kidney disease. A significant clinical challenge is relative resistance to erythropoietin, which … Continue reading

Research Article: Effects of Intraosseous Erythropoietin during Hemorrhagic Shock in Swine

Date Published: November 3, 2014 Publisher: Public Library of Science Author(s): Vesna Borovnik-Lesjak, Kasen Whitehouse, Alvin Baetiong, Yang Miao, Brian M. Currie, Sathya Velmurugan, Jeejabai Radhakrishnan, Raúl J. Gazmuri, Raghavan Raju. Abstract: To determine whether erythropoietin given during hemorrhagic shock (HS) ameliorates organ injury while improving resuscitation and survival. Three series of 24 pigs … Continue reading

Research Article: Erythropoietin Levels in Elderly Patients with Anemia of Unknown Etiology

Date Published: June 16, 2016 Publisher: Public Library of Science Author(s): Zachary Gowanlock, Swetha Sriram, Alison Martin, Anargyros Xenocostas, Alejandro Lazo-Langner, Wolfgang E.B. Jelkmann. Abstract: In many elderly patients with anemia, a specific cause cannot be identified. This study investigates whether erythropoietin levels are inappropriately low in these cases of “anemia of unknown etiology” … Continue reading

Research Article: Systemic Administration of Erythropoietin Inhibits Retinopathy in RCS Rats

Date Published: August 13, 2014 Publisher: Public Library of Science Author(s): Weiyong Shen, Sook H. Chung, Mohammad R. Irhimeh, Shiying Li, So-Ra Lee, Mark C. Gillies, Jing Chen. Abstract: Royal College of Surgeons (RCS) rats develop vasculopathy as photoreceptors degenerate. The aim of this study was to examine the effect of erythropoietin (EPO) on … Continue reading

Research Article: Does Erythropoietin Cause Hemoglobin Variability- Is It ‘Normal’?

Date Published: April 7, 2014 Publisher: Public Library of Science Author(s): Ashwani K Gupta, Waseem David, Zoran Ivanovic. Abstract: Hemoglobin variability (Hb-var) in patients with chronic kidney disease has been stipulated to be a result of exogenous treatment with erythropoiesis stimulating agents (ESA) and has been related to mortality in dialysis patients. We hypothesized … Continue reading

Research Article: Age-Dependent Astroglial Vulnerability to Hypoxia and Glutamate: The Role for Erythropoietin

Date Published: October 4, 2013 Publisher: Public Library of Science Author(s): Ali Lourhmati, Gayane H. Buniatian, Christina Paul, Stephan Verleysdonk, Reinhild Buecheler, Marine Buadze, Barbara Proksch, Matthias Schwab, Christoph H. Gleiter, Lusine Danielyan, François Blachier. Abstract: Extracellular accumulation of toxic concentrations of glutamate (Glu) is a hallmark of many neurodegenerative diseases, often accompanied by … Continue reading