G-protein | definition

a membrane protein activated by the hormone first messenger to activate formation of cyclic AMP


Clark, M., Douglas, M., Choi, J. Biology 2e. Houston, Texas: OpenStax. Access for free at: https://openstax.org/details/books/biology-2e


Research Article: The Repertoire of Heterotrimeric G Proteins and RGS Proteins in Ciona intestinalis

Date Published: October 6, 2009 Publisher: Public Library of Science Author(s): R. Prasobh, Narayanan Manoj, Janet Kelso. http://doi.org/10.1371/journal.pone.0007349 Abstract: Heterotrimeric G proteins and regulators of G protein signaling (RGS) proteins are key downstream interacting partners in the G protein coupled receptor (GPCR) signaling pathway. The highly versatile GPCR transmembrane signaling system is a consequence of the … Continue reading

Research Article: Conventional and Novel Gγ Protein Families Constitute the Heterotrimeric G-Protein Signaling Network in Soybean

Date Published: August 10, 2011 Publisher: Public Library of Science Author(s): Swarup Roy Choudhury, Naveen C. Bisht, Rheannon Thompson, Oleg Todorov, Sona Pandey, Deanna Koepp. http://doi.org/10.1371/journal.pone.0023361 Abstract: Heterotrimeric G-proteins comprised of Gα, Gβ and Gγ proteins are important signal transducers in all eukaryotes. The Gγ protein of the G-protein heterotrimer is crucial for its proper targeting … Continue reading

Research Article: Applications of molecular replacement to G protein-coupled receptors

Date Published: November 01, 2013 Publisher: International Union of Crystallography Author(s): Andrew C. Kruse, Aashish Manglik, Brian K. Kobilka, William I. Weis. http://doi.org/10.1107/S090744491301322X Abstract: The use of molecular replacement in solving the structures of G protein-coupled receptors is discussed, with specific examples being described in detail. Partial Text Transmembrane signaling plays a critical role in … Continue reading

Research Article: Light control of G protein signaling pathways by a novel photopigment

Date Published: October 1, 2018 Publisher: Public Library of Science Author(s): Tomás Osorno, Oscar Arenas, Nelson J. Ramírez-Suarez, Fabio A. Echeverry, María del Pilar Gomez, Enrico Nasi, Steven Barnes. http://doi.org/10.1371/journal.pone.0205015 Abstract: Channelopsins and photo-regulated ion channels make it possible to use light to control electrical activity of cells. This powerful approach has lead to a … Continue reading

Research Article: Inhibition of Dopamine Transporter Activity by G Protein βγ Subunits

Date Published: March 26, 2013 Publisher: Public Library of Science Author(s): Jennie Garcia-Olivares, Delany Torres-Salazar, William A. Owens, Tracy Baust, David P. Siderovski, Susan G. Amara, Jun Zhu, Lynette C. Daws, Gonzalo E. Torres, Jean-Pierre Mothet. http://doi.org/10.1371/journal.pone.0059788 Abstract: Uptake through the Dopamine Transporter (DAT) is the primary mechanism of terminating dopamine signaling within the brain, thus … Continue reading

Research Article: Detection of Cyclic Diguanylate G-Octaplex Assembly and Interaction with Proteins

Date Published: January 7, 2013 Publisher: Public Library of Science Author(s): Ori J. Lieberman, Jeffery J. DeStefano, Vincent T. Lee, Hung Ton-That. http://doi.org/10.1371/journal.pone.0053689 Abstract: Bacterial signaling networks control a wide variety of cellular processes including growth, metabolism, and pathogenesis. Bis-(3′–5′)-cyclic dimeric guanosine monophosphate (cdiGMP) is a secondary signaling nucleotide that controls cellulose synthesis, biofilm formation, motility … Continue reading

Research Article: Heteromerization of Ciliary G Protein-Coupled Receptors in the Mouse Brain

Date Published: September 27, 2012 Publisher: Public Library of Science Author(s): Jill A. Green, Chen Gu, Kirk Mykytyn, Jeffrey K. Harrison. http://doi.org/10.1371/journal.pone.0046304 Abstract: Nearly every cell type in the mammalian body projects from its cell surface a primary cilium that provides important sensory and signaling functions. Defects in the formation or function of primary cilia have … Continue reading

Research Article: Induction of RAGE Shedding by Activation of G Protein-Coupled Receptors

Date Published: July 30, 2012 Publisher: Public Library of Science Author(s): Verena V. Metz, Elzbieta Kojro, Dorothea Rat, Rolf Postina, Hiroaki Matsunami. http://doi.org/10.1371/journal.pone.0041823 Abstract: The multiligand Receptor for Advanced Glycation End products (RAGE) is involved in various pathophysiological processes, including diabetic inflammatory conditions and Alzheimes disease. Full-length RAGE, a cell surface-located type I membrane protein, can … Continue reading

Research Article: The Origin and Evolution of G Protein-Coupled Receptor Kinases

Date Published: March 19, 2012 Publisher: Public Library of Science Author(s): Arcady Mushegian, Vsevolod V. Gurevich, Eugenia V. Gurevich, Roland Seifert. http://doi.org/10.1371/journal.pone.0033806 Abstract: G protein-coupled receptor (GPCR) kinases (GRKs) play key role in homologous desensitization of GPCRs. GRKs phosphorylate activated receptors, promoting high affinity binding of arrestins, which precludes G protein coupling. Direct binding to active … Continue reading

Research Article: Molecular Evolution of the Transmembrane Domains of G Protein-Coupled Receptors

Date Published: November 21, 2011 Publisher: Public Library of Science Author(s): Sarosh N. Fatakia, Stefano Costanzi, Carson C. Chow, David Liberles. http://doi.org/10.1371/journal.pone.0027813 Abstract: G protein-coupled receptors (GPCRs) are a superfamily of integral membrane proteins vital for signaling and are important targets for pharmaceutical intervention in humans. Previously, we identified a group of ten amino acid positions … Continue reading