glucagon | definition

  • hormone produced by the alpha cells of the pancreas in response to low blood sugar
  • functions to raise blood sugar levels

Source:

Clark, M., Douglas, M., Choi, J. Biology 2e. Houston, Texas: OpenStax. Access for free at: https://openstax.org/details/books/biology-2e

Research Article: Bioactivity of a modified human Glucagon-like peptide-1

Date Published: February 2, 2017 Publisher: Public Library of Science Author(s): Fangfang Xu, Kevin Yueju Wang, Nan Wang, Gangqiang Li, Dehu Liu, Michael Bader. http://doi.org/10.1371/journal.pone.0171601 Abstract: Diabetes has become the third largest cause of death in humans worldwide. Therefore, effective treatment for this disease remains a critical issue. Glucagon-like peptide-1 (GLP-1) plays an important role … Continue reading

Research Article: Acute Glucagon Induces Postprandial Peripheral Insulin Resistance

Date Published: May 11, 2015 Publisher: Public Library of Science Author(s): Rita S. Patarrão, W. Wayne Lautt, M. Paula Macedo, Marcia B. Aguila. http://doi.org/10.1371/journal.pone.0127221 Abstract: Glucagon levels are often moderately elevated in diabetes. It is known that glucagon leads to a decrease in hepatic glutathione (GSH) synthesis that in turn is associated with decreased postprandial … Continue reading

Research Article: Modulation of β-Catenin Signaling by Glucagon Receptor Activation

Date Published: March 16, 2012 Publisher: Public Library of Science Author(s): Jiyuan Ke, Chenghai Zhang, Kaleeckal G. Harikumar, Cassandra R. Zylstra-Diegel, Liren Wang, Laura E. Mowry, Laurence J. Miller, Bart O. Williams, H. Eric Xu, Cara Gottardi. http://doi.org/10.1371/journal.pone.0033676 Abstract: The glucagon receptor (GCGR) is a member of the class B G protein–coupled receptor family. Activation of … Continue reading

Research Article: Model for Glucagon Secretion by Pancreatic α-Cells

Date Published: March 7, 2012 Publisher: Public Library of Science Author(s): Virginia González-Vélez, Geneviève Dupont, Amparo Gil, Alejandro González, Iván Quesada, Kathrin Maedler. http://doi.org/10.1371/journal.pone.0032282 Abstract: Glucagon hormone is synthesized and released by pancreatic α-cells, one of the islet-cell types. This hormone, along with insulin, maintains blood glucose levels within the physiological range. Glucose stimulates glucagon release … Continue reading

Research Article: Pancreatic Neuroendocrine Tumors in Glucagon Receptor-Deficient Mice

Date Published: August 10, 2011 Publisher: Public Library of Science Author(s): Run Yu, Deepti Dhall, Nicholas N. Nissen, Cuiqi Zhou, Song-Guang Ren, Amanda Ewart Toland. http://doi.org/10.1371/journal.pone.0023397 Abstract: Inhibition of glucagon signaling causes hyperglucagonemia and pancreatic α cell hyperplasia in mice. We have recently demonstrated that a patient with an inactivating glucagon receptor mutation (P86S) also exhibits … Continue reading

Research Article: Insulin and Glucagon Regulate Pancreatic α-Cell Proliferation

Date Published: January 25, 2011 Publisher: Public Library of Science Author(s): Zhuo Liu, Wook Kim, Zhike Chen, Yu-Kyong Shin, Olga D. Carlson, Jennifer L. Fiori, Li Xin, Joshua K. Napora, Ryan Short, Juliana O. Odetunde, Qizong Lao, Josephine M. Egan, Adrian Vella. http://doi.org/10.1371/journal.pone.0016096 Abstract: Type 2 diabetes mellitus (T2DM) results from insulin resistance and β-cell dysfunction, … Continue reading

Research Article: Establishment of a Refined Oral Glucose Tolerance Test in Pigs, and Assessment of Insulin, Glucagon and Glucagon-Like Peptide-1 Responses

Date Published: February 9, 2016 Publisher: Public Library of Science Author(s): Elin Manell, Patricia Hedenqvist, Anna Svensson, Marianne Jensen-Waern, Eric Xu. http://doi.org/10.1371/journal.pone.0148896 Abstract: Diabetes mellitus is increasing worldwide and reliable animal models are important for progression of the research field. The pig is a commonly used large animal model in diabetes research and the present … Continue reading

Research Article: Glucagon like receptor 1/ glucagon dual agonist acutely enhanced hepatic lipid clearance and suppressed de novo lipogenesis in mice

Date Published: October 24, 2017 Publisher: Public Library of Science Author(s): Vijay R. More, Julie Lao, David G. McLaren, Anne-Marie Cumiskey, Beth Ann Murphy, Ying Chen, Stephen Previs, Steven Stout, Rajesh Patel, Santhosh Satapati, Wenyu Li, Edward Kowalik, Daphne Szeto, Andrea Nawrocki, Alessandro Pocai, Liangsu Wang, Paul Carrington, Jonathan M. Peterson. http://doi.org/10.1371/journal.pone.0186586 Abstract: Lipid lowering … Continue reading

Research Article: Glucagon like receptor 1/ glucagon dual agonist acutely enhanced hepatic lipid clearance and suppressed de novo lipogenesis in mice

Date Published: October 24, 2017 Publisher: Public Library of Science Author(s): Vijay R. More, Julie Lao, David G. McLaren, Anne-Marie Cumiskey, Beth Ann Murphy, Ying Chen, Stephen Previs, Steven Stout, Rajesh Patel, Santhosh Satapati, Wenyu Li, Edward Kowalik, Daphne Szeto, Andrea Nawrocki, Alessandro Pocai, Liangsu Wang, Paul Carrington, Jonathan M. Peterson. http://doi.org/10.1371/journal.pone.0186586 Abstract: Lipid lowering … Continue reading

Research Article: Abscisic Acid Stimulates Glucagon-Like Peptide-1 Secretion from L-Cells and Its Oral Administration Increases Plasma Glucagon-Like Peptide-1 Levels in Rats

Date Published: October 21, 2015 Publisher: Public Library of Science Author(s): Santina Bruzzone, Mirko Magnone, Elena Mannino, Giovanna Sociali, Laura Sturla, Chiara Fresia, Valeria Booz, Laura Emionite, Antonio De Flora, Elena Zocchi, Claudia Miele. http://doi.org/10.1371/journal.pone.0140588 Abstract: In recent years, Abscisic Acid (ABA) has been demonstrated to be involved in the regulation of glucose homeostasis in … Continue reading


Source:

Clark, M., Douglas, M., Choi, J. Biology 2e. Houston, Texas: OpenStax. Access for free at: https://openstax.org/details/books/biology-2e