glucocorticoid | definition

corticosteroid that affects glucose metabolism


Clark, M., Douglas, M., Choi, J. Biology 2e. Houston, Texas: OpenStax. Access for free at:

Research Article: Glucocorticoid Regulation of Astrocytic Fate and Function

Date Published: July 21, 2011 Publisher: Public Library of Science Author(s): Shuang Yu, Silei Yang, Florian Holsboer, Nuno Sousa, Osborne F. X. Almeida, Cesario V. Borlongan. Abstract: Glial loss in the hippocampus has been suggested as a factor in the pathogenesis of stress-related brain disorders that are characterized by dysregulated glucocorticoid (GC) secretion. However, little … Continue reading

Research Article: The Origin of Glucocorticoid Hormone Oscillations

Date Published: June 5, 2012 Publisher: Public Library of Science Author(s): Jamie J. Walker, Francesca Spiga, Eleanor Waite, Zidong Zhao, Yvonne Kershaw, John R. Terry, Stafford L. Lightman, Antonio J. Vidal-Puig Abstract: Characterization of a peripheral hormonal system identifies the origin and mechanisms of regulation of glucocorticoid hormone oscillations in rats. Partial Text: A fundamental … Continue reading

Research Article: Effect of combining glucocorticoids with Compound A on glucocorticoid receptor responsiveness in lymphoid malignancies

Date Published: May 8, 2018 Publisher: Public Library of Science Author(s): Dorien Clarisse, Karlien Van Wesemael, Jan Tavernier, Fritz Offner, Ilse M. Beck, Karolien De Bosscher, Arun Rishi. Abstract: Glucocorticoids (GCs) are a cornerstone in the treatment of lymphoid malignancies such as multiple myeloma (MM) and acute lymphoblastic leukemia (ALL). Yet, prolonged GC use … Continue reading

Research Article: AMPK Mediates Glucocorticoids Stress-Induced Downregulation of the Glucocorticoid Receptor in Cultured Rat Prefrontal Cortical Astrocytes

Date Published: August 11, 2016 Publisher: Public Library of Science Author(s): Shi-Ying Yuan, Jue Liu, Jun Zhou, Wei Lu, Hai-Yun Zhou, Li-Hong Long, Zhuang-Li Hu, Lan Ni, Yi Wang, Jian-Guo Chen, Fang Wang, Luc Bertrand. Abstract: Chronic stress induces altered energy metabolism and plays important roles in the etiology of depression, in which the … Continue reading

Research Article: Suppression of the Nrf2-Dependent Antioxidant Response by Glucocorticoids and 11β-HSD1-Mediated Glucocorticoid Activation in Hepatic Cells

Date Published: May 11, 2012 Publisher: Public Library of Science Author(s): Denise V. Kratschmar, Diego Calabrese, Jo Walsh, Adam Lister, Julia Birk, Christian Appenzeller-Herzog, Pierre Moulin, Chris E. Goldring, Alex Odermatt, Zhi-Min Yuan. Abstract Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key transcription factor regulating a plethora of detoxifying enzymes and antioxidant genes involved … Continue reading

Research Article: Dibutyltin Disrupts Glucocorticoid Receptor Function and Impairs Glucocorticoid-Induced Suppression of Cytokine Production

Date Published: October 28, 2008 Publisher: Public Library of Science Author(s): Christel Gumy, Charlie Chandsawangbhuwana, Anna A. Dzyakanchuk, Denise V. Kratschmar, Michael E. Baker, Alex Odermatt, Joseph P. R. O. Orgel. Abstract: Organotins are highly toxic and widely distributed environmental chemicals. Dibutyltin (DBT) is used as stabilizer in the production of polyvinyl chloride plastics, and … Continue reading

Research Article: Insight into glucocorticoid receptor signalling through interactome model analysis

Date Published: November 6, 2017 Publisher: Public Library of Science Author(s): Emyr Bakker, Kun Tian, Luciano Mutti, Constantinos Demonacos, Jean-Marc Schwartz, Marija Krstic-Demonacos, Andrey Rzhetsky Abstract: Glucocorticoid hormones (GCs) are used to treat a variety of diseases because of their potent anti-inflammatory effect and their ability to induce apoptosis in lymphoid malignancies through the glucocorticoid … Continue reading

Research Article: Glucocorticoids Reduce Sepsis by Diminishing Dendritic Cell Responses

Date Published: October 6, 2015 Publisher: Public Library of Science Author(s): Richard Robinson Abstract: How does the body’s immune system strike the delicate balance between under- and over-response? A new study shows that glucocorticoids limit the production of the proinflammatory cytokine interleukin-12 by dendritic cells in response to invading bacteria, thereby helping to avoid sepsis. … Continue reading

Research Article: Characterization of a rabbit osteoporosis model induced by ovariectomy and glucocorticoid

Date Published: June 21, 2010 Publisher: Informa Healthcare Author(s): Li Baofeng, Yuan Zhi, Chen Bei, Meng Guolin, Yin Qingshui, Liu Jian. Abstract: Experimental models of osteoporosis in rabbits are useful to investigate anabolic agents because rabbits have an active Haversian remodeling and achieve skeletal maturiaty quickly. In this study, an experimental model of osteoporosis … Continue reading

Research Article: The effect of glucocorticoids on tendon cell viability in human tendon explants

Date Published: June 05, 2009 Publisher: Informa Healthcare Author(s): Margaret Wan Nar Wong, Wai Ting Lui, Sai Chuen Fu, Kwong Man Lee. Abstract: Background and purpose Previous studies on the culture of human tenocytes have shown that dexamethasone and triamcino-lone reduce cell viability, suppress cell proliferation, and reduce collagen synthesis. However, such cell cultures … Continue reading