gluconeogenesis | definition

synthesis of glucose from amino acids


Clark, M., Douglas, M., Choi, J. Biology 2e. Houston, Texas: OpenStax. Access for free at:


Research Article: Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei

Date Published: December 27, 2018 Publisher: Public Library of Science Author(s): Julie Kovářová, Rupa Nagar, Joana Faria, Michael A. J. Ferguson, Michael P. Barrett, David Horn, Julius Lukeš. Abstract: Bloodstream form African trypanosomes are thought to rely exclusively upon glycolysis, using glucose as a substrate, for ATP production. Indeed, the pathway has long been … Continue reading

Research Article: Gluconeogenesis is essential for trypanosome development in the tsetse fly vector

Date Published: December 17, 2018 Publisher: Public Library of Science Author(s): Marion Wargnies, Eloïse Bertiaux, Edern Cahoreau, Nicole Ziebart, Aline Crouzols, Pauline Morand, Marc Biran, Stefan Allmann, Jane Hubert, Oriana Villafraz, Yoann Millerioux, Nicolas Plazolles, Corinne Asencio, Loïc Rivière, Brice Rotureau, Michael Boshart, Jean-Charles Portais, Frédéric Bringaud, Scott M. Landfear. Abstract: In the glucose-free … Continue reading

Research Article: A Reduction in Age-Enhanced Gluconeogenesis Extends Lifespan

Date Published: January 14, 2013 Publisher: Public Library of Science Author(s): Mayumi Hachinohe, Midori Yamane, Daiki Akazawa, Kazuhiro Ohsawa, Mayumi Ohno, Yuzu Terashita, Hiroshi Masumoto, Deanna M. Koepp. Abstract: The regulation of energy metabolism, such as calorie restriction (CR), is a major determinant of cellular longevity. Although augmented gluconeogenesis is known to occur in aged … Continue reading

Research Article: Mapping MKP-3/FOXO1 Interaction and Evaluating the Effect on Gluconeogenesis

Date Published: July 25, 2012 Publisher: Public Library of Science Author(s): Ping Jiao, Bin Feng, Haiyan Xu, Ferenc Gallyas. Abstract MAP kinase phosphatase 3 (MKP-3) is known to attenuate the ERK signaling pathway. It has been recently demonstrated that MKP-3 is also a player in promoting hepatic glucose output in obese state by interacting and … Continue reading

Research Article: The Histone Demethylase Jhdm1a Regulates Hepatic Gluconeogenesis

Date Published: June 14, 2012 Publisher: Public Library of Science Author(s): Dongning Pan, Chunxiao Mao, Tie Zou, Annie Y. Yao, Marcus P. Cooper, Victor Boyartchuk, Yong-Xu Wang, Juleen R. Zierath Abstract: Hepatic gluconeogenesis is required for maintaining blood glucose homeostasis; yet, in diabetes mellitus, this process is unrestrained and is a major contributor to fasting … Continue reading

Research Article: In Silico Evidence for Gluconeogenesis from Fatty Acids in Humans

Date Published: July 21, 2011 Publisher: Public Library of Science Author(s): Christoph Kaleta, Luís F. de Figueiredo, Sarah Werner, Reinhard Guthke, Michael Ristow, Stefan Schuster, Markus W. Covert Abstract: The question whether fatty acids can be converted into glucose in humans has a long standing tradition in biochemistry, and the expected answer is “No”. Using … Continue reading

Research Article: Fitness of Escherichia coli during Urinary Tract Infection Requires Gluconeogenesis and the TCA Cycle

Date Published: May 29, 2009 Publisher: Public Library of Science Author(s): Christopher J. Alteri, Sara N. Smith, Harry L. T. Mobley, Jorge E. Galán. Abstract: Microbial pathogenesis studies traditionally encompass dissection of virulence properties such as the bacterium’s ability to elaborate toxins, adhere to and invade host cells, cause tissue damage, or otherwise disrupt … Continue reading

Research Article: The combination of NAD+-dependent deacetylase gene deletion and the interruption of gluconeogenesis causes increased glucose metabolism in budding yeast

Date Published: March 26, 2018 Publisher: Public Library of Science Author(s): Hiroshi Masumoto, Shigeru Matsuyama, Marie-Joelle Virolle. Abstract: Metabolic engineering focuses on rewriting the metabolism of cells to enhance native products or endow cells with the ability to produce new products. This engineering has the potential for wide-range application, including the production of fuels, … Continue reading

Research Article: Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation

Date Published: January 20, 2017 Publisher: Public Library of Science Author(s): Clinton M. Hasenour, D. Emerson Ridley, Freyja D. James, Curtis C. Hughey, E. Patrick Donahue, Benoit Viollet, Marc Foretz, Jamey D. Young, David H. Wasserman, Luc Bertrand. Abstract: AMPK is an energy sensor that protects cellular energy state by attenuating anabolic and promoting … Continue reading

Research Article: The FBPase Encoding Gene glpX Is Required for Gluconeogenesis, Bacterial Proliferation and Division In Vivo of Mycobacterium marinum

Date Published: May 27, 2016 Publisher: Public Library of Science Author(s): Jingfeng Tong, Lu Meng, Xinwei Wang, Lixia Liu, Liangdong Lyu, Chuan Wang, Yang Li, Qian Gao, Chen Yang, Chen Niu, Olivier Neyrolles. Abstract: Lipids have been identified as important carbon sources for Mycobacterium tuberculosis (Mtb) to utilize in vivo. Thus gluconeogenesis bears a … Continue reading