Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency (OpenStax Chemistry 2e)
Enzymes in the human body act as catalysts for important chemical reactions in cellular metabolism. As such, a deficiency of a particular enzyme can translate to a life-threatening disease. G6PD (glucose-6-phosphate dehydrogenase) deficiency, a genetic condition that results in a shortage of the enzyme glucose-6-phosphate dehydrogenase, is the most common enzyme deficiency in humans. This enzyme, shown in Figure 1, is the rate-limiting enzyme for the metabolic pathway that supplies NADPH to cells (Figure 2).
A disruption in this pathway can lead to reduced glutathione in red blood cells; once all glutathione is consumed, enzymes and other proteins such as hemoglobin are susceptible to damage. For example, hemoglobin can be metabolized to bilirubin, which leads to jaundice, a condition that can become severe. People who suffer from G6PD deficiency must avoid certain foods and medicines containing chemicals that can trigger damage their glutathione-deficient red blood cells.
Flowers, P., Theopold, K., Langley, R., & Robinson, W. R. (2019, February 14). Chemistry 2e. Houston, Texas: OpenStax. Access for free at: https://openstax.org/books/chemistry-2e
Research Article: Recombinant human G6PD for quality control and quality assurance of novel point-of-care diagnostics for G6PD deficiency
Date Published: May 26, 2017 Publisher: Public Library of Science Author(s): Maria Kahn, Nicole LaRue, Changcheng Zhu, Sampa Pal, Jack S. Mo, Lynn K. Barrett, Steve N. Hewitt, Mitchell Dumais, Sandra Hemmington, Adrian Walker, Jeff Joynson, Brandon T. Leader, Wesley C. Van Voorhis, Gonzalo J. Domingo, Luzia Helena Carvalho. http://doi.org/10.1371/journal.pone.0177885 Abstract: A large gap for … Continue reading
Research Article: First Evaluation of Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in Vivax Malaria Endemic Regions in the Republic of Korea
Date Published: May 22, 2014 Publisher: Public Library of Science Author(s): Youn-Kyoung Goo, So-Young Ji, Hyun-Il Shin, Jun-Hye Moon, Shin-Hyung Cho, Won-Ja Lee, Jung-Yeon Kim, Laurent Rénia. http://doi.org/10.1371/journal.pone.0097390 Abstract: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect and affects more than 400 million people worldwide. This deficiency is believed to protect against … Continue reading
Research Article: Impact of the Method of G6PD Deficiency Assessment on Genetic Association Studies of Malaria Susceptibility
Date Published: September 30, 2009 Publisher: Public Library of Science Author(s): Marla K. Johnson, Tamara D. Clark, Denise Njama-Meya, Philip J. Rosenthal, Sunil Parikh, James G. Beeson. http://doi.org/10.1371/journal.pone.0007246 Abstract: Clinical association studies have yielded varied results regarding the impact of glucose-6-phosphate dehydrogenase (G6PD) deficiency upon susceptibility to malaria. Analyses have been complicated by varied methods used … Continue reading
Research Article: Evaluation of the Diagnostic Accuracy of CareStart G6PD Deficiency Rapid Diagnostic Test (RDT) in a Malaria Endemic Area in Ghana, Africa
Date Published: April 17, 2015 Publisher: Public Library of Science Author(s): Dennis Adu-Gyasi, Kwaku Poku Asante, Sam Newton, David Dosoo, Sabastina Amoako, George Adjei, Nicholas Amoako, Love Ankrah, Samuel Kofi Tchum, Emmanuel Mahama, Veronica Agyemang, Kingsley Kayan, Seth Owusu-Agyei, Luzia Helena Carvalho. http://doi.org/10.1371/journal.pone.0125796 Abstract: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most widespread enzyme defect that … Continue reading