Highlights: Vitamin D Deficiency As A Predictor of Poor Prognosis in Patients with Acute Respiratory Failure Due to COVID-19


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  • Research Info: 2020 Aug 9. doi: 10.1007/s40618-020-01370-x
  • Vitamin D deficiency is a highly spread condition associated with increased risk of respiratory tract infections.
  • Cytokine storm is associated with disease severity.
  • The goal of this research is to analyze vitamin D levels in patients with acute respiratory failure due to COVID-19 and to determine any association with the severity and prognosis of the disease.
  • This retrospective and observational research analyzed 42 patients from Policlinic of Bari with acute respiratory failure due to COVID-19 from March 11 to April 30, 2020.
  • About 81 percent of the patients had vitamin D deficiency.
  • After 10 days of hospitalization, patients with severe vitamin D deficiency had a 50 percent mortality probability.
  • Patients with vitamin D greater than 10 ng/mL had a 5 percent mortality risk.
  • Vitamin D deficiency is prevalent in COVID-19 patients with acute respiratory failure treated in respiratory intensive care unit.
  • Patients with severe vitamin D deficiency had a significantly higher mortality risk.
  • Severe vitamin D deficiency may be a marker of poor prognosis in these patients.
  • This study suggests that adjunctive treatment might improve disease outcomes.