insulin-like growth factor | definition

growth-promoting protein produced by the liver


Clark, M., Douglas, M., Choi, J. Biology 2e. Houston, Texas: OpenStax. Access for free at:


Research Article: Modeling the Insulin-Like Growth Factor System in Articular Cartilage

Date Published: June 26, 2013 Publisher: Public Library of Science Author(s): Lihai Zhang, David W. Smith, Bruce S. Gardiner, Alan J. Grodzinsky, Amina Ann Qutub. Abstract: IGF signaling is involved in cell proliferation, differentiation and apoptosis in a wide range of tissues, both normal and diseased, and so IGF-IR has been the focus of intense … Continue reading

Research Article: Doxorubicin Impairs the Insulin-Like Growth Factor-1 System and Causes Insulin-Like Growth Factor-1 Resistance in Cardiomyocytes

Date Published: May 8, 2015 Publisher: Public Library of Science Author(s): Patrizia Fabbi, Paolo Spallarossa, Silvano Garibaldi, Chiara Barisione, Marzia Mura, Paola Altieri, Barbara Rebesco, Maria Gaia Monti, Marco Canepa, Giorgio Ghigliotti, Claudio Brunelli, Pietro Ameri, Partha Mukhopadhyay. Abstract: Insulin-like growth factor-1 (IGF-1) promotes the survival of cardiomyocytes by activating type 1 IGF receptor … Continue reading

Research Article: Insulin-Like Growth Factor-1 but Not Insulin Predicts Cognitive Decline in Huntington’s Disease

Date Published: September 14, 2016 Publisher: Public Library of Science Author(s): Linda Salem, Nadine Saleh, Gaelle Désaméricq, Katia Youssov, Guillaume Dolbeau, Laurent Cleret, Marie-Laure Bourhis, Jean-Philippe Azulay, Pierre Krystkowiak, Christophe Verny, Françoise Morin, Stéphane Moutereau, Anne-Catherine Bachoud-Lévi, Patrick Maison, David Blum. Abstract: Huntington’s disease (HD) is one of several neurodegenerative disorders that have been … Continue reading

Research Article: Associations of Insulin and Insulin-Like Growth Factors with Physical Performance in Old Age in the Boyd Orr and Caerphilly Studies

Date Published: January 10, 2012 Publisher: Public Library of Science Author(s): Kate Birnie, Yoav Ben-Shlomo, Jeff M. P. Holly, David Gunnell, Shah Ebrahim, Antony Bayer, John Gallacher, Richard M. Martin, Yiqing Song. Abstract: Insulin and the insulin-like growth factor (IGF) system regulate growth and are involved in determining muscle mass, strength and body composition. We … Continue reading

Research Article: Understanding the Mechanism of Insulin and Insulin-Like Growth Factor (IGF) Receptor Activation by IGF-II

Date Published: November 28, 2011 Publisher: Public Library of Science Author(s): Clair L. Alvino, Shee Chee Ong, Kerrie A. McNeil, Carlie Delaine, Grant W. Booker, John C. Wallace, Briony E. Forbes, Elizabeth Wilson. Abstract: Insulin-like growth factor-II (IGF-II) promotes cell proliferation and survival and plays an important role in normal fetal development and placental function. … Continue reading

Research Article: Insulin-Like Growth Factor I (IGF-1) Ec/Mechano Growth Factor – A Splice Variant of IGF-1 within the Growth Plate

Date Published: October 11, 2013 Publisher: Public Library of Science Author(s): Werner Schlegel, Adalbert Raimann, Daniel Halbauer, Daniela Scharmer, Susanne Sagmeister, Barbara Wessner, Magdalena Helmreich, Gabriele Haeusler, Monika Egerbacher, Francisco J. Esteban. Abstract: Human insulin-like growth factor 1 Ec (IGF-1Ec), also called mechano growth factor (MGF), is a splice variant of insulin-like growth factor … Continue reading

Research Article: Low Insulin-Like Growth Factor-1 Level in Obesity Nephropathy: A New Risk Factor?

Date Published: May 3, 2016 Publisher: Public Library of Science Author(s): Ioana Bancu, Maruja Navarro Díaz, Assumpta Serra, Marisa Granada, Dolores Lopez, Ramon Romero, Josep Bonet, Abelardo I Aguilera. Abstract: IGF-1 (insulin-like growth factor-1) is a hormone involved in cell growth and other important processes. In the kidney, IGF-1 has a stimulating effect, increasing … Continue reading

Research Article: Targeting Insulin-Like Growth Factor 1 Receptor Inhibits Pancreatic Cancer Growth and Metastasis

Date Published: May 8, 2014 Publisher: Public Library of Science Author(s): Ramadevi Subramani, Rebecca Lopez-Valdez, Arunkumar Arumugam, Sushmita Nandy, Thiyagarajan Boopalan, Rajkumar Lakshmanaswamy, Lucia R. Languino. Abstract: Pancreatic cancer is one of the most lethal cancers. Increasing incidence and mortality indicates that there is still much lacking in detection and management of the disease. … Continue reading

Research Article: Insulin-Like Growth Factor 1 Receptor Is a Prognostic Factor in Classical Hodgkin Lymphoma

Date Published: January 28, 2014 Publisher: Public Library of Science Author(s): Zheng Liang, Arjan Diepstra, Chuanhui Xu, Gustaaf van Imhoff, Wouter Plattel, Anke Van Den Berg, Lydia Visser, Martin Rowe. Abstract: The interaction between the tumor cells in classical Hodgkin lymphoma (cHL) and the microenvironment includes aberrant activity of receptor tyrosine kinases. In this … Continue reading

Research Article: Membrane-To-Nucleus Signaling Links Insulin-Like Growth Factor-1- and Stem Cell Factor-Activated Pathways

Date Published: October 7, 2013 Publisher: Public Library of Science Author(s): Yujiro Hayashi, David T. Asuzu, Simon J. Gibbons, Kirsten H. Aarsvold, Michael R. Bardsley, Gwen A. Lomberk, Angela J. Mathison, Michael L. Kendrick, K. Robert Shen, Takahiro Taguchi, Anu Gupta, Brian P. Rubin, Jonathan A. Fletcher, Gianrico Farrugia, Raul A. Urrutia, Tamas Ordog, Anette … Continue reading